Enhanced delivery platform for biomolecule uptake in plants
A cutting-edge platform enhancing the cellular delivery of dsRNA, proteins, and nanoparticles into plant cells to modify traits and increase viral resistance. Demonstrated effective knockdown of plant transcripts and potential for transient trait modification.
Overview
This innovative platform significantly enhances the delivery of biomolecules such as double-stranded RNA (dsRNA), proteins, and nanoparticles into plant cells, paving the way for temporal modification of plant traits. By improving the uptake efficiency of these molecules, the platform enables effective knockdown of plant transcripts and increased resistance to viruses. This capability is crucial for developing plants with desired traits and improving their resilience against pathogens.
Technical specifications
Key features:
- Enhanced uptake of dsRNA leading to up to 1000-fold knockdown of target transcripts
- Effective delivery demonstrated in various plant tissues, including seedlings and adult leaves
- Capability to deliver proteins and nanoparticles such as Layered Double Hydroxide (LDH) into plant cells
- Versatile platform potentially applicable for both RNA and protein-based trait modifications
Technology readiness level
Currently at TRL 4, the platform has been validated under controlled conditions for its ability to enhance biomolecule uptake. Future validation efforts include optimizing formulations for specific tissues and expanding trials to economically important crops like canola and tomato.
About The University of Queensland
The University of Queensland is a large, multi-campus public research university in Brisbane with a comprehensive academic and research profile. Industry partners engage through hospital-embedded laboratories and clinical sites, pilot testbeds, and field campuses across Queensland that enable prototyping, trials, and validation in real-world settings. Co-location with major health precincts and proximity to Brisbane’s innovation districts make collaboration and talent access straightforward, while on-campus incubation and professional education support workforce upskilling. Research is supported by competitive national funding from the Australian Research Council and the National Health and Medical Research Council, alongside state and industry investment. A dedicated technology transfer office and commercialization company manage IP, licensing, sponsored research agreements, and spin-out formation.
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