Enhancement of micronutrients oral bioavailability via SNEDDS encapsulation

Overview

The proposed solution leverages self-nanoemulsifying drug delivery systems (SNEDDS) to address the challenge of low oral bioavailability of lipophilic micronutrients. By encapsulating these nutrients in SNEDDS, the technology aims to enhance their solubilization, permeability, and absorption, ultimately improving their efficacy. This approach could facilitate lymphatic absorption and act as a permeation enhancer, leading to increased oral absorption of micronutrients.

Technical specifications

The technology involves the encapsulation of micronutrients using GRAS (generally regarded as safe) excipients such as long- and medium-chain glycerides, nonionic surfactants, and cosurfactants. The SNEDDS formulations are designed to enhance nutrient delivery by optimizing droplet size, zeta potential, and stability in simulated intestinal media. Key features include:

• Increased micronutrient loading and stability towards lipases
• High mucus permeating properties
• In vitro tested for droplet size distribution, zeta potential, and cytotoxicity
• Evaluation of cell uptake and crossing of the intestinal epithelium

Technology readiness level

The current TRL is 3, indicating that the technology has been validated in a laboratory environment. Future steps involve further in vitro testing and potential in vivo evaluations to advance its development.