Ex vivo models for neurodegeneration research
Innovative ex vivo models using mouse synaptosomes and isolated cortex specimens to study neurotransmitter activity and neuropeptide pathways in neurodegenerative diseases. These models facilitate screening of neuroprotective agents and study of antioxidant effects.
Overview
This research focuses on developing innovative ex vivo models to study neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's disease (PD). Utilizing mouse brain synaptosomes and isolated cortex specimens, these models aim to evaluate neurotransmission processes and the effects of neurodegenerative agents. They provide valuable insights into the potential protective effects of antioxidants on neurotransmitter pathways and offer a rapid screening method for neuroprotective agents.
Technical specifications
Models Used:
- Mouse Brain Synaptosomes: Used to study neurotransmitter release and turnover. This model is valuable for assessing the impact of neurodegenerative agents and the protective effects of antioxidants on biogenic amine pathways.
- Isolated Mouse Cortex Specimens: Designed to evaluate neuropeptides, enzymes (such as MAOs and COMTs), and cytokines. This model facilitates the study of metabolic pathways and the assessment of anti-inflammatory and antioxidant effects.
Experimental Phases:
- Months 1-3: Focus on neurotransmitter synthesis and release in synaptosomes under conditions mimicking AD and PD.
- Months 3-6: Investigate neuropeptides and neurotransmission enzymes in isolated brain tissues under similar conditions.
Technology readiness level
The research is currently at Technology Readiness Level 3, indicating that the models are in the experimental proof-of-concept stage, with ongoing validation under various experimental conditions to simulate AD and PD environments.
About Universita degli Studi Gabriele d'Annunzio di Chieti e Pescara
Università degli Studi “Gabriele d’Annunzio” Chieti–Pescara is a comprehensive public university serving the Abruzzo region, with two campuses and an affiliated teaching hospital. Co‑located clinical, preclinical, and analytical facilities enable industry to prototype, validate, and scale with academic partners. The university maintains structured pathways for collaboration, including sponsored research, contract services, student placements, and tailored short courses coordinated through central liaison offices. Research draws on competitive European and Italian support, including Horizon Europe, national ministries, and regional innovation programs. A dedicated technology transfer office manages IP, licensing, spin‑outs, and collaboration agreements, and helps companies access shared instrumentation.
Inquire about this partnering listing
Industry applications
delivered to your inbox.