Evaluation of neuromodulatory effects of caffeine and nootropics on dopamine metabolism and neuropeptide expression
Research platform investigating how caffeine and nootropic compounds influence dopamine metabolism, related enzymatic pathways, and hypothalamic neuropeptides involved in learning and memory. Offers in vitro validation u...
In vitro screening platform for bioactives and botanicals targeting circadian biology
A scalable in vitro screening platform using HypoE22 hypothalamic neurons to evaluate dietary bioactives, nutraceutical ingredients, and botanical extracts for sleep and circadian rhythm support. Delivers mechanistic ins...
Natural compound screening platform for 5-alpha reductase inhibitors
Research platform identifying phenolic and phytosterol compounds from medicinal plants that inhibit 5-alpha reductase. Combines in silico docking and network pharmacology with in vitro validation using prostate cell mode...
Investigating the role of TRPM8 receptor modulation in parkinson's disease neuroprotection
A preclinical research program exploring the transient receptor potential melastatin subtype 8 (TRPM8) channel as a novel therapeutic target in Parkinson's disease. The study uses an isolated mouse brain striatum model e...
Ex vivo models for neurodegeneration research
Innovative ex vivo models using mouse synaptosomes and isolated cortex specimens to study neurotransmitter activity and neuropeptide pathways in neurodegenerative diseases. These models facilitate screening of neuroprote...
Predictive models for herbicide toxicity and biocompatibility
A comprehensive project to evaluate the toxicity and biocompatibility of herbicides using alternative models like allelopathy and Artemia salina assays, alongside the inclusion of phytocompounds to enhance formulation sa...
Herbal extract solutions for skin disorder protection
Innovative herbal extracts from medicinal plants like Vitis vinifera and Cannabis sativa are being developed to address skin disorders. These extracts demonstrate antioxidant and enzyme inhibition effects, with in vitro ...
Modulatory effects of herbal extracts on estrogen pathway for hair health
Exploring the potential of herbal extracts to modulate estrogen pathways, promoting hair health through mechanisms like phytoestrogen interaction and anti-inflammatory effects, supported by in vitro and ex vivo studies.
Herbal extracts for modulation of feeding behavior
Exploring the use of herbal extracts to modulate feeding behavior by affecting hypothalamic and peripheral signaling, focusing on neuropeptides and biogenic amines. This research investigates their role in regulating app...
Xenobiotic modulation of sodium/glucose cotransporter gene expression
This study investigates the potential of xenobiotics to restore sodium/glucose cotransporter levels in colon cells under inflammatory conditions in vitro. The research aims to evaluate the blunting effect of xenobiotics ...
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