Fluorescence-based non-contact measurement of VEGF in sweat
A fluorescence-based technique for non-contact measurement of vascular endothelial growth factor (VEGF) levels in sweat, sensitive enough to detect changes induced by sodium lauryl sulfate (SLS) exposure.
Overview
This innovative technology utilizes a fluorescence-based non-contact approach to measure vascular endothelial growth factor (VEGF) levels in sweat. By addressing the sensitivity challenges in detecting VEGF, this method can detect changes induced by exposure to sodium lauryl sulfate (SLS). The capability to monitor VEGF levels non-invasively offers significant potential for applications in dermatological research and health monitoring.
Technical specifications
The system is calibrated to detect VEGF concentrations as low as 6 pM, leveraging a fluorescence-based measurement approach. This sensitivity is crucial for identifying increases in VEGF levels, which are hypothesized to double upon SLS exposure. The technology operates without direct contact, reducing potential contamination and improving patient comfort. This method could be particularly useful in continuous health monitoring and non-invasive diagnostic applications.
Technology readiness level
Currently, the technology is at a TRL 4, indicating that it has been validated in a laboratory setting. Further development and testing are required to transition this technology to a higher readiness level suitable for broader clinical and commercial use.
About University of Cincinnati
The University of Cincinnati is a comprehensive public research university with an applied, urban-serving character and a significant clinical enterprise. Industry engages through one of the nation's largest cooperative education programs, placing students year-round with corporate R&D and operations teams and creating an on-ramp to sponsored research. An innovation district near campus hosts co-located corporate labs, startup space, and shared prototyping facilities, while the university's integration with a major hospital system enables clinical studies and translation. Research is supported by competitive federal funding from agencies such as NIH and NSF, along with state and industry partnerships. A dedicated technology transfer office manages IP, licensing, corporate agreements, and startup formation, providing flexible models for collaboration.
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