Gene-Cloned Entomopathogenic Fungi Formulation for Sustainable Bagworm Pest Control

Technology
In development
University

A biological pest control solution using Isaria fumosorosea, an entomopathogenic fungus effective against bagworm pests in oil palm and other crops. The project aims to clone key fungal genes to enable scalable mass production, offering a safe, eco-friendly alternative to chemical pesticides that protects pollinators and human health.

Overview

This research addresses the urgent need for sustainable pest management in agriculture by developing a biological control formulation based on Isaria fumosorosea, a naturally occurring entomopathogenic fungus. The solution targets bagworm pests, which are destructive lepidopteran insects that threaten oil palm and other crops. Field validation studies have already demonstrated that I. fumosorosea formulations can suppress bagworm populations below the economic threshold level within 45 days of application, with effects lasting up to 60 days. The product offers a compelling alternative to broad-spectrum chemical insecticides, providing effective pest suppression while remaining safe for pollinators, humans, and the broader environment.

Technical specifications

Key features:

  • Based on Isaria fumosorosea, a cosmopolitan entomopathogenic fungus with proven efficacy against multiple insect species
  • Utilizes chitinase enzymes produced by the fungus to degrade insect cuticles and initiate infection
  • Demonstrated ability to reduce bagworm (Metisa plana) populations below the economic threshold of 10 larvae per frond
  • Effective pest suppression lasting up to two months in field conditions
  • Safe for non-target organisms including pollinators and humans
  • Planned gene cloning approach to transfer specific virulence-related genes into alternative host organisms for easier and more cost-effective mass production

Applications:

  • Oil palm plantations facing bagworm infestations
  • Other agricultural crops affected by lepidopteran pests
  • Integrated pest management programs seeking to reduce chemical pesticide dependency
Technology readiness level

The formulation has completed initial field validation, demonstrating significant population reductions of bagworm pests in crop environments. The current TRL reflects successful proof-of-concept and preliminary efficacy data from field trials. The next phase involves gene cloning to enhance production scalability, with planned work in bioreactor-based mass production and formulation development. Additional field trials are required to generate robust data sets for commercial adoption. The project timeline is approximately one year for the gene cloning and production scale-up phase, with ongoing field validation to build the evidence base needed for market entry and customer confidence.


About Universiti Putra Malaysia

Universiti Putra Malaysia (UPM) is a comprehensive public research university in Serdang, Greater Kuala Lumpur, with a campus that integrates classroom, laboratory, and field-testing environments. Companies engage through co-located labs, on-campus testbeds, and university-run farms that enable prototyping and trials close to production supply chains. Health system integration and proximity to Putrajaya’s ministries and the Cyberjaya tech corridor facilitate collaboration and timely access to partners. Research is supported by competitive funding from Malaysia’s Ministry of Higher Education, the Ministry of Science, Technology and Innovation, and international sponsors. A dedicated technology transfer office manages IP, licensing, and startup support, connecting companies with faculty expertise and specialized facilities.

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