Human-relevant in vitro platforms for wound healing and compound screening

Overview

The REGEN platform offers a cutting-edge solution for wound healing and regenerative research, providing a human-relevant in vitro screening system. This technology employs organotypic skin models and scalable regeneration assays to enable precise, quantitative evaluation of compounds that influence processes like migration, proliferation, extracellular matrix remodeling, and tissue repair. With its ability to support medium- to high-throughput screening, the platform ensures efficient, reproducible workflows. The integration of AI-based image analysis allows for objective quantification of wound migration, tissue morphology, and regenerative responses, enhancing the accuracy and predictive power of compound assessments.

Technical specifications

• Organotypic skin models: Mimic multicellular interactions and tissue-level responses, enhancing biological relevance compared to traditional 2D assays.
• Automated imaging and AI analysis: Provides detailed, quantitative data on wound closure, migration kinetics, proliferation, and tissue remodeling.
• Scalable assays: Compatible with repeated dosing and longitudinal monitoring, allowing for comprehensive endpoint analyses such as immunofluorescence, ELISA, cytokine profiling, and ECM marker quantification.
• Flexible integration: Can incorporate advanced organotypic wound models, such as fibrotic or scar-like environments, for more physiologically relevant studies.

Technology readiness level

This platform is currently at Technology Readiness Level 3, indicating that it has been validated in a laboratory environment and is ready for further development through collaborative research engagements.