Metagenomics-driven antimicrobial peptides for gingivitis treatment
A novel platform utilizing metagenomics to mine antimicrobial peptides (AMPs) from oral bacteria, formulated as postbiotics in oral care products to treat gingivitis. This targeted approach restores ecological balance without harming beneficial bacteria.
Overview
This innovative solution leverages a cutting-edge platform that utilizes metagenomics to identify and extract antimicrobial peptides (AMPs) from oral microbiota. These AMPs are then used as heat-inactivated postbiotics in toothpaste or mouthwash formulations to effectively treat gingivitis. By targeting specific pathogenic bacteria while preserving beneficial ones, this approach provides a novel method to restore and maintain oral health without disrupting the microbiome balance.
Technical specifications
- Metagenomic mining: Utilizes advanced algorithms (AMPLiT and AMPidentifier) to screen small open reading frames in metagenome-assembled genomes.
- Chemical synthesis: AMPs are synthesized with >95% purity for inclusion in oral care products.
- Targeted action: Focused on health-associated bacteria such as Rothia mucilaginosa and Neisseria spp., which naturally produce AMPs that suppress harmful pathogens.
- Validation: In vitro and in vivo tests for efficacy, stability, and safety, including a rat model for periodontal disease.
Technology readiness level
Currently at TRL 3, this solution has been validated in laboratory settings and is undergoing further testing to prepare for regulatory approval and commercial development.
About Dalian University of Technology
Dalian University of Technology is a leading public research university in northeast China with a strong engineering core and broad interdisciplinary programs. Industry partners engage through co-located laboratories, joint research institutes, and specialized testing and prototyping facilities. A university-affiliated science and technology park and proximity to the Dalian High-Tech Zone give companies convenient access to talent, facilities, and regional supply chains. Research is supported by competitive national funding in China, including the National Natural Science Foundation of China and the Ministry of Science and Technology, plus provincial and industry support. A dedicated technology transfer office supports IP strategy, licensing, startup incubation, and collaborative agreements.
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