Postbiotic-based modulation of oral biofilms to counteract gingivitis

Overview

This postbiotic-based solution aims to revolutionize oral care by targeting the microbiome associated with gingivitis. By utilizing inactivated beneficial oral commensals and their bioactive metabolites, this formulation selectively modulates dysbiotic oral biofilms. Incorporated into a chewing gum format, the postbiotic provides prolonged release of active compounds, promoting a health-associated microbial balance and counteracting gingivitis. This approach addresses the underlying microbial dysbiosis rather than targeting specific pathogens, offering a sustainable and effective oral care strategy.

Technical specifications

• Postbiotic Composition: Utilizes inactivated beneficial oral commensals (e.g., selected Streptococcus spp.)
• Delivery System: Chewing gum format for prolonged residence and continuous release
• Analysis Techniques: Multi-omics analyses (metagenomics and metabolomics) to monitor microbiome shifts
• Compatibility: Can be integrated with existing oral care formulations
• Safety and Stability: Non-viable system avoids regulatory challenges associated with live microorganisms

Technology readiness level

The development is at Technology Readiness Level 2, with ongoing phase-based validation. Current efforts include candidate selection, in vitro validation using multispecies oral biofilm models, and formulation into a chewing gum prototype. Future phases will focus on pilot validation and clinical evaluations to further establish efficacy and scalability.