Microvascular detection platform for surfactant exposure
A clinical platform utilizing Laser Doppler Flowmetry to detect early microvascular responses in skin exposed to low-level surfactants, enabling differentiation of mild surfactant systems through sensitive perfusion profiles.
Overview
This innovative clinical platform leverages Laser Doppler Flowmetry (LDF) technology to detect subtle microvascular responses in the skin when exposed to low-level surfactants. By integrating resting skin blood flow with functional testing, the platform provides an early indication of neurovascular and endothelial changes prior to visible irritation. This approach is particularly valuable for differentiating mild surfactant systems, offering a significant advantage over traditional irritation assessments.
Technical specifications
Key features:
- Utilizes Laser Doppler Flowmetry for continuous, objective skin perfusion measurement
- Evaluates acute and chronic inflammatory responses through repeated, site-specific measurements
- Functional testing includes local thermal response and pharmacologic approaches
- Stratified analysis based on sex, age, anatomical site, and skin characteristics
- Capable of simulating real-world exposure scenarios with both rinse-off and leave-on conditions
Applications:
- Differentiation of mild surfactant systems in personal care and cosmetic industries
- Early detection of subclinical changes in neurovascular and endothelial function
- Development of more sensitive and relevant dermatological assessments
Technology readiness level
This technology is currently at TRL 6, having been validated in controlled clinical studies with human subjects. Future validation will involve further controlled studies to assess recovery kinetics and simulate real-world exposure conditions.
About Kansas State University
Kansas State University is a comprehensive public land‑grant research university with multiple campuses and a strong applied mission. Industry partners tap a statewide extension network that connects companies to field sites, talent, and rapid outreach; campus pilot plants and analytical services enable bench‑to‑pilot scale validation, while co‑located high‑containment facilities support regulated studies. The Olathe campus in the Kansas City metro serves as an industry‑engagement hub with workforce pipelines, collaborative labs, and proximity to the Kansas City Animal Health Corridor. Research is supported by competitive federal funding from agencies such as NSF, NIH, USDA, and DOE, alongside state and corporate sponsors, and a dedicated technology transfer office streamlines IP, sponsored research, and startup formation.
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