Mycotoxin detection using immuno-mrm technology

Overview

Our innovative mycotoxin detection solution leverages immuno-MRM technology, which combines the precision of mass spectrometry (LC-MS) with the specificity of high-affinity antibodies. This method is particularly effective in detecting trace amounts of mycotoxins in complex grain matrices, providing a critical tool for food safety and quality assurance. By isolating and quantifying these harmful compounds, our technology ensures that even minute quantities are accurately detected, thereby helping to prevent potential health risks associated with mycotoxin exposure.

Technical specifications

• High-affinity antibodies: Developed to target mycotoxin peptide fragments, our antibodies exhibit low off-rate characteristics, enhancing their ability to concentrate and isolate target molecules.
• Immunoaffinity isolation: The technology employs antibodies conjugated to a solid support, allowing for effective capture and concentration of target peptides prior to LC-MS analysis.
• LC-MS detection: This method ensures a clean and simple mass spectrometry profile, facilitating accurate quantification using stable isotope-labeled peptide tracers.
• Versatile application methods: Includes two LC-MS detection methods, either through complete protease digestion of purified mycotoxins or direct immunoaffinity isolation of intact mycotoxins.

Technology readiness level

The current technology readiness level is 3, indicating that the core components and principles of the technology have been validated in a laboratory environment. Ongoing efforts focus on further validation steps, including peptide fragment development, antibody generation against peptides, and quantification assays, to advance the technology toward commercial readiness.