Peptide-based pest control technologies for enhanced bt formulations
Develop innovative peptide-based bio-pesticides to enhance Bt formulations, offering novel modes of action against resistant lepidopteran pests. These peptides improve the efficacy and durability of DiPel® against Bt-resistant strains, promoting sustainable crop protection.
Overview
The Danforth Plant Science Center is pioneering the development of peptide-based pest control technologies to combat the growing issue of pest resistance to synthetic insecticides. By utilizing cysteine-rich antimicrobial peptides derived from plant defensins, this research aims to enhance existing Bacillus thuringiensis (Bt) formulations, specifically DiPel®, against resistant lepidopteran pests like the Diamondback moth. This approach not only introduces new modes of action (MoAs) but also promotes the stability and sustainability of crop protection strategies.
Technical specifications
- Innovative MoAs: Utilizes plant-derived cysteine-rich peptides to enhance Bt formulations.
- Synergy with existing products: Demonstrates improved efficacy of DiPel® through novel interactions with defensins.
- Production method: Peptides can be produced via fermentation, offering a cost-effective and scalable solution.
- Target pests: Focus on lepidopteran pests, including Bt-resistant strains of the Diamondback moth.
Technology readiness level
Currently at TRL 3, this technology has been proven in a laboratory setting. Future validation will involve detailed bioassays to determine lethal concentrations and potential synergistic effects, paving the way for further development and potential commercial applications.
About Danforth Plant Science Center
The Donald Danforth Plant Science Center is a leading independent, nonprofit research institute in St. Louis with a multidisciplinary research community focused on plant science. Corporate engagement is built into the campus through co‑located labs, flexible leased space, and shared core facilities that enable side‑by‑side collaboration with startups and established R&D teams. Its location within a regional agtech innovation district places partners near major corporate hubs, venture networks, and field‑to‑lab testing resources. Research is supported by competitive federal funding from agencies such as the NSF, USDA, and DOE, alongside industry‑sponsored projects and philanthropy. A dedicated technology transfer office provides IP management, licensing, and venture formation support.
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