Peptide mediators interfacing taste and body mass regulation
Innovative research explores the role of satiety peptides in modulating taste bud cell responses, potentially impacting food intake and obesity management. By studying peptide overexpression in saliva, the project aims to develop therapeutic strategies for dietary control.
Overview
Researchers at Georgia State University are investigating the role of satiety peptides such as GLP-1, PYY, and PP in modulating taste bud cell (TBC) responses. This study aims to understand how these peptides affect taste perception, potentially influencing food intake and energy balance. By exploring the hormonal modulation of chemosensory perception, this research seeks to develop novel strategies for managing obesity and related lifestyle diseases.
Technical specifications
The project tests several hypotheses regarding the impact of satiety peptides on taste responsiveness. Key experiments involve:
- Imaging of TBCs: Using live cell calcium and sodium imaging, and ATP secretion assays on isolated mouse and human TBCs to assess functional changes.
- Behavioral analyses: Conducting psychophysical measurements and meal pattern analysis in mice with increased salivary peptide levels.
- Transgene treatment: Utilizing rAAV vectors to enhance peptide expression in salivary glands and study resultant changes in taste sensitivity and ingestive behavior.
Technology readiness level
This research is at Technology Readiness Level 3, indicating active research and development with proof of concept established through laboratory studies. Future work will focus on validating these findings and exploring therapeutic applications.
About Georgia State University
Georgia State University is a comprehensive public research university in downtown Atlanta, serving a large and diverse student body with a rapidly growing research enterprise. An urban innovation district and co-located collaboration spaces link faculty and students with corporate partners for prototyping, user testing, and joint problem-solving. Shared core laboratories and campus computing resources support industry-sponsored work, while proximity to Fortune 500 headquarters, major hospital systems, and the CDC enables quick access to real-world testbeds. Research is backed by competitive federal funding from agencies such as NIH, NSF, and DoD. A dedicated technology transfer office streamlines IP, licensing, and startup formation to speed commercialization.
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