Programmable protein coatings for functional particle surfaces
Innovative in silico designed protein coatings offer tunable adhesion and responsiveness for particle surfaces. Leveraging recent advances in computational biochemistry, these coatings provide customizable solutions for diverse applications with minimal experimental work.
Overview
Programmable protein coatings represent a groundbreaking approach to functionalizing particle surfaces. By utilizing in silico methods to design proteins with tunable adhesion and responsiveness to external stimuli, this technology offers customizable solutions for various applications. Leveraging recent advances in AI-driven computational biochemistry, we can design de novo proteins that interact optimally with target materials, providing a flexible and cost-effective alternative to traditional empirical methods.
Technical specifications
- Protein-particle interface engineering: Utilizing machine learning models and Monte Carlo simulations to identify and optimize material-specific proteins.
- De novo protein optimization: Re-scaffolding selected protein interfaces into stable designs suitable for recombinant or chemical synthesis.
- Stimuli-responsive coatings: Engineering proteins for pH-responsive or ligand-triggered modulation of particle surfaces.
- In vitro validation: Top candidates are synthesized and characterized using techniques such as ITC, Zetasizer, and AFM for binding, stability, and structure.
Technology readiness level
The technology is currently at TRL 2, with ongoing in silico development and planned in vitro validation to further advance its readiness.
About University of Lincoln
The University of Lincoln is a comprehensive public university with a modern, city-centre campus and an applied research culture. Industry engagement is built into its model through co-located facilities at a dedicated science and innovation park and long-term partnerships with global manufacturers, utilities, and regional SMEs. Specialized food manufacturing and packaging testbeds at its south Lincolnshire campus provide pilot-scale lines for process development, while links with regional NHS trusts and a medical school enable clinical research and evaluation. Research draws competitive support from UKRI councils, Innovate UK, and the National Institute for Health and Care Research, alongside partnerships with industry. A dedicated technology transfer and enterprise office supports IP management, licensing, and spinout formation.
Inquire about this partnering listing
Looking for
delivered to your inbox.