Root-targeted VLP nanoparticle platform for enhanced fungicide efficacy
A root-targeted nanoparticle platform using engineered virus-like particles to enhance fungicide efficacy by improving delivery and reducing resistance in soilborne pathogens. Utilizes RNA interference and co-formulated strategies for crop-specific tuning.
Overview
The proposed solution is a root-targeted nanoparticle platform that aims to enhance the efficacy of commercial fungicides against persistent soilborne fungal pathogens. This innovative approach utilizes engineered Tobacco Mild Green Mosaic Virus (TMGMV) virus-like particles (VLPs) and spherical nanoparticles (SNPs) to improve fungicide delivery, employ RNA interference for targeted gene knockdown, and create novel co-formulated compositions. The platform is designed to increase bioavailability at the root-pathogen interface, offer new modes of action, and disable fungal resistance mechanisms, thereby prolonging fungicide utility and reducing environmental impact.
Technical specifications
The platform integrates three strategies, each increasing in mechanistic precision:
- Simple Co-formulation: Utilizes untreated TMGMV VLPs or SNPs co-applied with fungicides, enhancing fungicide concentration at the root zone.
- Bioconjugated Fungicide Delivery: Involves covalent attachment of fungicides to VLP/SNP surfaces, increasing local doses and improving targeting.
- VLP-Encapsulated RNAi + Fungicide: Encapsulates self-cleaving ssRNA that produces siRNA targeting resistance genes, co-delivered with fungicides for dual action. These strategies are adaptable for soil drench or root dip applications across various crops and pathogens.
Technology readiness level
The current technology readiness level is 4, indicating that the platform has been validated in a laboratory environment. Further development and testing are planned to advance its readiness for commercial applications.
About Northeastern University
Northeastern University is a private, comprehensive R1 research university based in Boston with a global campus network. Its century-old cooperative education model integrates full-time, paid placements with academic study, enabling companies to access vetted talent and long-term pipelines worldwide. Industry collaboration is supported by a suburban innovation campus offering test beds, secure labs, and fee-for-use core facilities, alongside co-located partner spaces. The university attracts competitive federal research funding from agencies such as the NSF and NIH. A dedicated technology transfer office streamlines IP, licensing, and startup formation for corporate partnerships.
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