Skin impedance spectroscopy for enhanced SC barrier function detection
A novel, highly sensitive skin impedance spectroscopy technique to detect small changes in stratum corneum barrier function, outperforming traditional methods. Validated in human and pig skin, it's ready for further studies with potential industry partners.
Overview
This innovative approach utilizes skin impedance spectroscopy to detect minute changes in the stratum corneum (SC) barrier function. By applying a low alternating voltage to the skin and measuring the resultant current across various frequencies, this method offers superior sensitivity compared to traditional techniques such as Trans-Epidermal Water Loss and SC moisture measurements. This technology has shown clear differentiation in skin resistance upon exposure to chemical irritants and pathogens, making it a valuable tool for skincare and dermatological research.
Technical specifications
- Method: Utilizes a low (100 mV) alternating voltage applied through standard ECG electrodes.
- Sensitivity: Demonstrated a significant change in skin impedance, exemplified by a reduction in resistance by a factor of ten after exposure to sodium dodecyl sulfate (SDS).
- Validation: Proven effective in both human and pig skin models when subjected to various stressors, including chemical and microbial irritants.
- Applications: Particularly useful in assessing the impact of detergents and skincare products on skin health.
Technology readiness level
This technology is at TRL 5, having been validated in relevant environments with human and animal skin models. The platform is ready for further validation studies tailored to specific industry needs, offering opportunities for co-development, sponsored research, or fee-for-service partnerships.
About University of Bath
The University of Bath is a research‑intensive public university in Bath, England, with a campus‑based, mid‑sized profile and a strong record of collaboration with business and the public sector. Industry engagement is built into its model through extensive professional placements that embed students in corporate R&D and through collaborative facilities available to partners; its location in the Bristol–Bath innovation corridor gives access to a dense tech and advanced engineering cluster. A dedicated Research and Innovation Services unit and corporate partnerships team broker sponsored research, consultancy, and facility access, while a university‑backed incubator within the SETsquared partnership connects companies to mentors, investors, and talent. Research is supported by competitive funding from UK Research and Innovation councils and Innovate UK, alongside European programmes. Commercialization is managed by a technology transfer team that supports IP, licensing, and spinout formation.
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