Strategic framework for discovering potentiators to overcome fungal resistance
A consultancy service to design a discovery and validation strategy for potentiators targeting fungicide resistance pathways. It focuses on TRL 2 concept development, preparing future PhD projects for TRL 3–4 validation with a structured, mechanistic approach.
Overview
This strategic framework offers a consultancy service aimed at designing a discovery and validation strategy for potentiators that target resistance pathways in fungicides, specifically CYP51, QoI, SDH, and Pol I. Potentiators are non-fungicidal compounds that restore the efficacy of fungicides, providing a regulatory-light solution to combat widespread resistance. This service focuses on TRL 2 concept development, enabling rapid ideation and preparation for future PhD projects that can progress through TRL 3–5.
Technical specifications
- Target Pathways: CYP51, QoI, SDH, Pol I
- Approach:
- Literature and database review to identify non-fungicidal synergists
- Definition of compound selection criteria
- Mode-of-action hypothesis proposal
- Tools and Methods:
- Computer-based drug development expertise
- Cheminformatics tools for scaffold selection
- In silico validation methods such as docking, MoA prediction, and toxicity assessments
- Output:
- Four modular, PhD-ready experimental plans, each specific to a target pathway
- Recommendations for TRL 3 assays including checkerboard MIC and synergy scoring
Technology readiness level
This consultancy project is currently at TRL 2, focusing on concept development. The service aims to prepare projects for progression to TRL 3–4, with future validation plans involving structured reviews and cheminformatics-guided scaffold selection to identify potential potentiators.
About University Editor
University Editor is a specialist academic editing service based in Pretoria, South Africa, founded in 2009. Led by Dr. Anastasia Apostolides, the service provides professional proofreading, formatting, and language editing for postgraduate students, specifically focusing on Master’s and PhD dissertations, theses, and research proposals. The company utilizes a combination of expert editorial review and AI-assisted tools to ensure compliance with university style guides, such as APA and Harvard, and to improve the clarity, conciseness, and technical accuracy of academic documents. All corrections are provided via tracked changes to facilitate student review.
This service is designed to help postgraduate researchers meet rigorous scholarly standards and improve their chances of success with examiners and supervisors. By addressing issues in grammar, syntax, and referencing, University Editor assists students in producing cohesive and professional research papers. The service has experience supporting students from various prominent South African institutions, and testimonials highlight its role in helping candidates achieve academic distinctions and secure acceptance into doctoral programs. It serves as a resource for those seeking to refine their academic writing while maintaining the integrity and quality of their research.
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