Supercritical co₂-fabricated liposomes in mucoadhesive films for enhanced mineral delivery
Innovative solution utilizing supercritical CO₂ technology to fabricate milk-derived liposomes embedded in mucoadhesive films. This system enhances mineral bioavailability via buccal absorption, providing a non-invasive method for effective nutritional supplementation.
Overview
This innovative solution leverages supercritical CO₂ (SCO₂) technology to fabricate milk-derived liposomes that encapsulate essential minerals for enhanced bioavailability. These liposomes are integrated into cellulose-based buccal mucoadhesive films, which adhere to the oral mucosa to facilitate direct absorption into the systemic circulation. This method significantly improves the stability and bioactivity of minerals, ensuring efficient delivery and absorption without gastrointestinal degradation. The non-invasive design provides a patient-friendly approach to mineral supplementation, especially beneficial for individuals with swallowing difficulties.
Technical specifications
- Supercritical CO₂ fabrication: Solvent-free method that encapsulates minerals within milk-derived liposomes, preserving their bioactivity.
- Mucoadhesive films: Made from cellulose-based materials, these films ensure prolonged contact with the buccal mucosa, aiding in controlled release and enhanced absorption.
- Liposome integration: Utilizes the Vent-RESS system, exploiting rapid expansion of supercritical solutions for efficient mineral incorporation.
- Targeted delivery: Bypasses gastrointestinal degradation and first-pass metabolism, optimizing mineral uptake.
Technology readiness level
Currently at TRL 3, the technology is in the experimental proof-of-concept stage. Future steps include optimizing mineral loading and mucoadhesive properties, followed by in vitro evaluations to assess delivery efficiency.
About Oregon State University
Oregon State University is a comprehensive public research university and Oregon’s land‑grant institution, with a main campus in Corvallis and a statewide footprint. Industry partners tap a statewide Extension network and county offices to pilot and scale solutions with communities and companies across Oregon. A coastal marine science campus in Newport anchors ocean research and provides access to open‑ocean wave‑energy test ranges and grid‑connected infrastructure under development nearby, enabling sea‑to‑shore prototyping. Field stations and university‑managed research forests support long‑term trials and product validation in real‑world environments. A dedicated technology transfer office and the OSU Advantage programs—including the Advantage Accelerator—streamline IP, licensing, startup formation, and industry agreements.
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