Xenobiotic modulation of sodium/glucose cotransporter gene expression
This study investigates the potential of xenobiotics to restore sodium/glucose cotransporter levels in colon cells under inflammatory conditions in vitro. The research aims to evaluate the blunting effect of xenobiotics on inflammation-induced gene expression alterations.
Overview
This research explores the potential of xenobiotics in modulating the gene expression of sodium/glucose cotransporters in an in vitro model of colon inflammation. The study is based on the pivotal role of oral rehydration solutions in treating acute intestinal inflammation by stimulating the sodium/glucose transporter SGLT1 to enhance fluid absorption. The main objective is to evaluate how xenobiotics can restore the transporter levels, offering a novel approach to managing intestinal inflammation.
Technical specifications
The study utilizes immortalized human colon cell lines exposed to E. coli lipopolysaccharides (LPS) to simulate inflammatory conditions similar to those found in dysbiosis. The effects of xenobiotics on the gene expression of sodium/glucose cotransporters, as well as markers of inflammation and oxidative stress, will be assayed. The in vitro model allows for rapid results within 4-8 weeks, providing insights into the potential therapeutic effects of xenobiotics in reducing inflammation-induced gene expression alterations.
Technology readiness level
The research is at Technology Readiness Level 3, indicating experimental proof of concept. The in vitro model is designed to provide preliminary data on the efficacy of xenobiotics in modulating transporter gene expression under inflammatory conditions.
About Universita degli Studi Gabriele d'Annunzio di Chieti e Pescara
Università degli Studi “Gabriele d’Annunzio” Chieti–Pescara is a comprehensive public university serving the Abruzzo region, with two campuses and an affiliated teaching hospital. Co‑located clinical, preclinical, and analytical facilities enable industry to prototype, validate, and scale with academic partners. The university maintains structured pathways for collaboration, including sponsored research, contract services, student placements, and tailored short courses coordinated through central liaison offices. Research draws on competitive European and Italian support, including Horizon Europe, national ministries, and regional innovation programs. A dedicated technology transfer office manages IP, licensing, spin‑outs, and collaboration agreements, and helps companies access shared instrumentation.
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