Yeast fermentation platforms for food, feed, and nutrition ingredients

Summary Renaissance BioScience has commercialized non-GM yeast strains for the global food industry and operates two established yeast platforms, a phenotyped biobank of 720 wild yeast strains and an engineered S. cerevisiae platform, for producing a wide range of ingredients for food, feed, and nutrition, from single-cell protein, lipids, probiotics, and postbiotics to enzymes, bioactive peptides, and other high-value compounds. Overview Renaissance BioScience brings proven yeast fermentation capability to ingredients for food, feed, and nutrition. We have commercialized non-GM yeast strains with global food ingredient companies, built and phenotyped a biobank of 720 wild yeast strains spanning 260+ taxonomic groups, and developed fermentation processes on low-cost substrates, including food side streams. Our engineered S. cerevisiae platform has validated heterologous protein and secreted peptide production. The wild yeast platform offers a non-GM route to yeast single-cell protein, microbial lipids, probiotic cultures, postbiotic beta-glucans and mannan-oligosaccharides, and a broad range of naturally produced enzymes. The engineered platform adds a route to specific target enzymes and bioactive peptides. Technical specifications • Wild yeast platform: biobank of 720 non-GM wild yeast strains, characterized by high-throughput phenotyping and including oleaginous species, with genome sequencing and AI-assisted strain discovery tools in development. • Engineered platform: precision fermentation in S. cerevisiae covering gene design, construct assembly, strain engineering, fermentation optimization, and analytical purity assessment. The platform has validated heterologous protein and secreted peptide production and avoids antibiotic resistance genes. • Substrates: conventional fermentation media and low-cost alternatives, including liquid food side streams such as dairy lactose permeate and agro-industrial residues. • Target products: o Yeast single-cell protein and protein- and lipid-rich biomass o Microbial lipids and oils from oleaginous yeasts o Probiotic yeast cultures o Postbiotic beta-glucans and mannan-oligosaccharides o Enzymes for food, feed, and industrial processing, including phytases, proteases, lipases, xylanases, glucanases, and other carbohydrate-active enzymes o Bioactive peptides Technology readiness level Strain discovery, engineered protein expression, and fermentation process development are established within our current programs. The next step is applying these to partner-defined target products and substrates, followed by process optimization, product characterization, and pilot-scale and application testing.