National University of Singapore
Explore National University of Singapore's available technologies.
Nanoneedle-enabled platform for precision integration of large DNA into crop genomes
Silicon nanoneedles physically deliver intact large DNA and CRISPR editing components together into plant cells, overcoming the delivery bottleneck that limits large-DNA genome engineering. Already validated for plasmids...
Conjugated Oligoelectrolytes: Modular Antimicrobial Compounds for Targeted Membrane Disruption
A class of modular antimicrobial compounds that disrupt microbial membranes with tunable specificity. The technology enables rational design of derivatives targeting Gram-positive/Gram-negative bacteria or fungi, while m...
Transdermal microneedle monoclonal antibody sponge for chronic skin inflammation
Minimally invasive microneedle platform loaded with monoclonal antibodies to continuously absorb and neutralize inflammatory proteins beneath the skin for at least 6 months. Targets chronic inflammatory skin conditions i...
IoT-based smart greenhouse environment management system for accelerated plant growth
An advanced IoT-based greenhouse management system that uses deep learning to automatically control CO2 release and environmental parameters (temperature, humidity) to accelerate plant growth. Built on proven building en...
Cyclophane-containing RiPPs targeting BamA for antibacterial applications
Novel ribosomally synthesized peptides with three-residue cyclophane rings that lock into a beta-strand conformation to bind BamA, an essential outer membrane protein in Gram-negative bacteria. Offers a potential new mod...
Biodegradable nano-needle platform for high-efficiency gene editing in plants
A biodegradable nano-needle technology that uses mechanoporation to deliver large genetic cargo into plant cells and tissues with over 90% efficiency. Designed for CRISPR/Cas gene editing to engineer crops with enhanced ...
Novel Bioretention System for Nitrogen Removal from Urban Stormwater Runoff
A patented engineered soil media and bioretention system designed to remove nitrogen and other pollutants from urban stormwater runoff. The system combines optimized filter media with submerged zones and native plant spe...
Spns2-targeted therapy for multiple sclerosis via S1P transporter inhibition
A novel therapeutic approach targeting the S1P transporter Spns2 for treatment of multiple sclerosis. Preclinical data in animal models demonstrate that blocking Spns2 inhibits lymphocyte trafficking and reduces neuroinf...
Iron-catalyzed nitrene ring-expansion for accessing novel agrochemical heterocycles
A sustainable catalytic method using earth-abundant iron to convert four-membered nitrogen heterocycles into five-membered pyrazolidines, isoxazolidines, and isothiazolidines—privileged scaffolds for next-generation crop...
High-throughput live-exudation platform for plant–microbiome screening
The Live-Exudation Assisted Phytobiome Cultromics System (LEAP-CS) is a high-throughput research platform designed for studying the chemical dialogue between plants and their microbiomes. By using a membrane-based co-cul...
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