MC
Marcelo Comini
Principal Investigator
Institut Pasteur de Montevideo
I'm working on
10 months ago
Parasitology, Redox Biology, Medicinal Chemistry
About
Studies thiol-redox pathways in protozoan pathogens to enable target validation and anti-infective discovery. Combines biochemistry, molecular/cell biology and medicinal chemistry with assay development and in vivo imaging to screen and advance candidate therapeutics.
Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis
Frontiers in Chemical Biology
•2024
Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening
Frontiers in Chemical Biology
•2024
Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity
International Journal for Parasitology Drugs and Drug Resistance
•2024
A FRET-based cGMP biosensor in Drosophila
MicroPubl Biol
•2023
Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance
Sensors
•2022
CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones
Front Mol Biosci
•2021
Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes
Journal of Biological Chemistry 283 (41), 27785-27798, 2008
Trypanothione synthesis in Crithidia revisited
Journal of Biological Chemistry 280 (8), 6850-6860, 2005
Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids
PLoS neglected tropical diseases 10 (4), e0004617, 2016
Validation of Trypanosoma brucei trypanothione synthetase as drug target
Free Radical Biology and Medicine 36 (10), 1289-1302, 2004
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum
Free Radical Biology and Medicine 73, 229-238, 2014
Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1
Walter de Gruyter 389 (1), 21-32, 2008
The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin
Journal of Biological Chemistry 281 (29), 20555-20566, 2006
Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei
Biochemical Journal 405 (3), 445-454, 2007
Oxidovanadium (IV) and dioxidovanadium (V) complexes of tridentate salicylaldehyde semicarbazones: searching for prospective antitrypanosomal agents
Journal of Inorganic Biochemistry 127, 150-160, 2013
Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection
Analytical Biochemistry 435 (1), 74-82, 2013
Biosynthesis of trypanothione in Trypanosoma brucei brucei
Walter de Gruyter 384 (4), 653-656, 2003
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism
Biochimica et Biophysica Acta (BBA)-General Subjects 1780 (11), 1236-1248, 2008
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification
Free Radical Biology and Medicine 45 (6), 733-742, 2008
Identification of novel bacterial plasminogen‐binding proteins in the human pathogen Mycobacterium tuberculosis
Proteomics 7 (18), 3332-3341, 2007
Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids
Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (5), 3199-3216, 2013
Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes
Biochemical Journal 402 (1), 43-49, 2007
New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents
Dalton Transactions 41 (5), 1534-1543, 2012
The trypanothione system
Peroxiredoxin Systems: Structures and Functions, 231-251, 2007
Measurement and meaning of cellular thiol: disufhide redox status
Free radical research 50 (2), 246-271, 2016
Evaluation of the diagnostic value of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of Mycobacterium tuberculosis in childhood tuberculosis
The International Journal of Tuberculosis and Lung Disease 5 (11), 1036-1043, 2001
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