We study the nutritional and functional quality of grains, ingredients and cereal-based ready-to-eat (RTE) foods. Our activities align with responsive agriculture and precision nutrition priorities to improve food quality for better health outcomes. We recently developed a rapid protocol for the determination of in vitro glycemic load based on 60 min digestion of carbohydrate-rich ready to eat food as a proxy for glycemic index. We believe this is an important information relevant to the modern food system to guide consumers, industry and regulatory agencies towards better health. This helps to manage blood glucose levels and related disease (type 2 diabetes affecting >40 M Americans). The new tool is fit for nutrition claims on cereal-based foods in addition to the calorie information.