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Elevating lactose and derivatives through innovative processes and applications
  • Background
  • What we're looking for
  • What we can offer you
  • Who we are
  • Q&A
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Get them answered by the team at Leprino Foods.
Background

Lactose is a disaccharide composed of glucose and galactose, commonly referred to as milk sugar, as it is recovered primarily from cow’s milk. There are multiple applications for lactose in a variety of industries, including food, beverages, pharmaceuticals, infant formula, and nutritional supplements. However, as a commodity-based ingredient, its pricing fluctuates depending on market pressures. Since lactose is typically saturating the marketplace, it is difficult to make the product profitable and to find high-volume uses. A potential solution would be to convert lactose into derivative compounds such as, but not limited to, lactobionic acid, lactitol, galacto-oligosaccharides, and lactulose, which could unlock new product and market opportunities.

What we're looking for

We are in search of transformative technologies that can elevate the value of lactose (including lactose, whey permeate, and de-lactose permeate/mother liquor) beyond its current commodity status. This could include processes that convert lactose into high-demand compounds, the development of high-value products incorporating lactose or its derivatives, and the creation of novel derivatives with scalable production methods and strong market potential. We are also exploring opportunities where lactose or its derivatives can serve as viable replacements for existing high-demand ingredients or compounds, as well as new market applications that expand the commercial potential of lactose-based solutions.

By pushing the boundaries of what is possible, we aim to revolutionize the use of lactose and/or its derivatives, creating innovative solutions that meet the evolving needs of various industries.

Solutions of interest include:
  • Applications for galactose or galactose-derived products
  • Applications for lactobionic acid and/or its salts
  • Applications for lactose-based hydrogels
  • Applications for lactose-based ingredients (e.g., cosmetics, medical applications, etc.)
  • Applications for lactulose
  • Applications for polylactose
  • Bioactive compounds for food preservation
  • Chemical, mechanical, enzymatic, electrochemical conversion of lactose to compounds of interest in materials and polymer chemistry
  • Fermentation of lactose into value-added compounds (i.e., materials/polymer chemistry)
  • Functional additives for industrial coatings
  • Use of lactose derivatives to replace ingredients used in ultra-processed foods
Our must-have requirements are:
  • For a new market opportunity, the potential to utilize a minimum of 13,000 tonnes (~28.6 million pounds) of lactose or lactose-derivatives per year
  • For process-based solutions, demonstration of technical feasibility (lab-scale validation or pilot data)
  • For process-based solutions, the potential for scalable production
  • In your proposed solution lactose should have a differentiated advantage over other cheap carbohydrates (i.e., glucose)
Our nice-to-have's are:
  • Application in green or sustainable technology
  • Capable of using refined (99%) or unrefined (30 to 78%) lactose (i.e., unrefined de-lactose permeate or permeate)
  • Cost-competitive with existing alternatives
  • Demonstrated market demand or industry partnerships
  • Non-toxic and biodegradable under standard conditions
  • Patentability or prior intellectual property protection
What's out of scope:
  • Ethanol production applications
  • Galacto-oligosaccharides
  • Poly-lactic acid
  • Traditional dairy applications (e.g., lactose-free products)
Acceptable technology readiness levels (TRL):
Levels 3-9
What we can offer you
Eligible partnership models:
Sponsored research
Benefits:
Sponsored Research
Up to $100,000 for 6-12 months Phase 1 activities, inclusive of 15% indirect costs for academic partners. Award amount is dependent on the scope of work.
Expertise
Access to industry mentors.
Tools and Technologies
Access to our pilot plant for scale up and development.
Compounds and Reagents
Delactose permeate, whey permeate and lactose.
Data
Analytical data of input materials, i.e., delactose permeate, whey permeate, and lactose.
Facilities and Services
Visit plants under supervision. Use of pilot-scale fermentation and analytical labs.
Who we are

We are dedicated to producing products and processes that set the standard for excellence.​ Our commitment to quality means that every product we produce is designed to deliver optimal performance, whether it’s enhancing health and wellness benefits or meeting the precise requirements of specialized applications, such as pharmaceutical tablets and infant formula.​

​We work closely with our partners to develop innovative solutions that leverage the unique properties of our products and work effectively in their end products.​

 Learn more
Reviewers
Q&A with Leprino Foods

The Q&A is now closed.

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Q.
We are an academic team have a related research on TRL stage 3-5, with a spun-out startup. Should we apply as the research group from the university or from the startup company.
1
A.
Hi Shelley, Thank you for your question. We're excited to hear about your interest in submitting a proposal. The proposal could come from either entity but perhaps the company is ideal as that is likely who we would contract with. kind regards, Richard
RM
Richard Merrill, VP Innovation, Leprino Foods
May 13, 2025
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0
Q.
How does intellectual property get divided here? Who is owning what is developed throughout the project?
1
A.
Hi Louis, Thank you for this great question. The division of intellectual property (IP) is something we are quite flexible to discussing and is generally developed as we discuss a project agreement, but here are some key points: - Any IP each party brings to the project remains the property of the original owner. - IP developed during the course of a project is owned according to the contributions and agreements made by the parties which can be divided as follows: - If IP is developed collaboratively, both parties may agree to joint ownership and each party has rights to use it. - If IP is developed primarily by one party, that party may retain sole ownership, with the other party receiving license to use the IP under agreed terms. Please let me know if there are other details to you question not addressed here. I'm certain whatever the situation we aim to find a win: win solution. I look forward to hearing from you and reviewing your proposal(s). Kind regards, Richard
RM
Richard Merrill, VP Innovation, Leprino Foods
April 2, 2025
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2
0
Q.
Hi Richard, Would you be interested in conversion of glucose/sucrose utilising strains that can already make mid/high value natural products into lactose-utilising strains?
1
A.
Yes, we would be interested in proposals that have the potential of “converting glucose/sucrose utilizing strains to lactose utilizing strains”, with the assumption that utilization of lactose can be cost competitive with existing alternatives (glucose/sucrose). A potential avenue to cost competitiveness might be if the strains can utilize unrefined (30 to 78%) lactose (i.e., unrefined de-lactose permeate or permeate).
RM
Richard Merrill, VP Innovation, Leprino Foods
April 17, 2025
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0
Q.
Would pharmaceutical manufacturing applications be considered, example, the use of lactose derivatives as functional excipients with integrated real-time analytical monitoring for process control and quality assurance?
1
A.
Hi Carlos, yes we are considering pharmaceutical applications in this RFP. We currently manufacture pharmaceutical lactose as a excipient and would be keen to understand your thoughts for adding to our portfolio. Kind regards, Richard
RM
Richard Merrill, VP Innovation, Leprino Foods
May 26, 2025
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