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Background
The development of genome-editing technology has enabled the modification of DNA sequences in genomes, allowing for the accurate removal or replacement of specific sequences in organisms and leading to targeted mutations. In the realm of plants, genome editing serves as an appealing approach to modify gene functions and produce enhanced crop varieties. This technology is considered user-friendly and carries a reduced likelihood of unintended consequences compared to traditional mutation breeding. Moreover, genome-editing tools can be directly applied to crops with intricate genomes and/or those that cannot be easily bred through conventional methods.
What we're looking for
We are seeking expertise in genome editing with CRISPR to enhance vegetable crops. We aim for genome editing approaches focused on known candidate genes within the plant genome, resulting in a targeted inversion of 2 Mbp, effectively linking two beneficial genes. To achieve this, we are looking for collaborations with experts currently having all the necessary genome editing laboratory capabilities. The ultimate objective is to attain genome-edited plants, and we are open to sponsoring research collaborations that align with this goal.
Our must-have requirements are:
- Applicants must have access to genome editing facility
- Applicants must have the ability to produce genome edited plants containing the desired genome modification and without off-target genome edits
What's out of scope:
- Agrobacterium-mediated plant transformation that leads to GMO plants
- Technologies addressing only portions of the process, such as improvement to plant regeneration and cargo delivery
Acceptable technology readiness levels (TRL):
Levels 1-7
What we can offer you
Eligible partnership models:
Co-developmentSponsored researchSupply/purchase
Benefits:
Sponsored Research
Sponsored research – we will screen the potential ideas and set up an appropriate strategic partnership (Proof of concepts typically range up to $300,000 for 2 years project per crop with potential follow up funding for 2-3 years).Expertise
We offer the expertise of our team of scientists for collaboration and guidance during the development of the project.Q&A with the company
The Q&A is now closed.
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Most upvoted
Q.
1. did you have candidate genes on specific crops?
2. genomes are available for the crops of interest?
3. any crossovers has been studied on the target region?
5
Q.
Which vegetable crop is of interest, and does this editing work need to be accomplished in a specific cultivar?
3
Q.
Would you consider doing this in a Brassica?
TL
November 17, 2023
2
Q.
What does 'out of scope' for the project mean in this instance? That, for example, Agro-mediated transformation is not able to be used?
BJ
November 1, 2023
2
Q.
Can the project be multi institutional (Indian Institution and a US Institution)?
1
Q.
Generally Solanaceae and Cucurbitaceae have little barriers for transformation and/or regeneration. Have location been mapped? Are targets part of multigene families? Have locations been mapped?
1
Q.
All the answers below indicate that there is no impediment to doing this editing? Do you not have access to lab, reagents and growth space?
1
Q.
Will you still consider base editing? Previously you showed interest in that, which is what we are trying on potato. However, we see the description now as 'target inversion of 2Mbp...'.
YX
November 24, 2023
1
Q.
Who supplies the plant/material? UC Santa Cruz can support the CRISPR work at our facility, but would not have direct interest in the plant growing activity (though we have a 36-acre farm that the company could access)
FE
Former Employee, Corporate Relations, University of California, Santa Cruz
October 23, 2023
1
Q.
Are there any restrictions regarding the applied methods (e.g. publicly available plasmids, patents, ...)?
October 30, 2023
1
Q.
Is a DNA-free approach preferred or would the use of a plasmid/selection marker be an option as well?
October 30, 2023
1
Is this response helpful?
0
0
Q.
Can we know more about the crop (crucial), the genes and the industrial link?
ZK
October 6, 2023
1
Q.
Are the generated plants thought to be used for breeding/commercialization immediately or is it a proof of principle?
October 30, 2023
1
Q.
'What’s out of scope: Agrobacterium-mediated plant transformation'
suggests that the specific method or technique of Agrobacterium-mediated transformation is not within the scope of the research?
November 15, 2023
1
A.
Thank you for your interest. Indeed 'What’s out of scope: Agrobacterium-mediated plant transformation' suggests that the specific method or technique of Agrobacterium-mediated transformation is not within the scope of the research. However, using Agrobacterium, which will in the end result in no presence of a novel genetic material in the generated plants, would be in the scope.
Is this response helpful?
0
0
Q.
Is there a quality full genome assemblly with annotation for the crop; is there a standardized transformation and regeneration protocol available? What is the seed to seed lifecycle like?
1
A.
Thank you for your interest. 1.Yes, a quality full genome assembly with annotation for the crop is available. 2. Standardized transformation and regeneration protocols are not available. That said, we would be open to any innovative transformation and regeneration protocols. 3. Unfortunately, we could not comment on seed to seed lifecycle at the moment.
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