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Mycotoxin detection, control, and reduction in corn processing
  • Background
  • What we're looking for
  • What we can offer you
  • Who we are
  • Q&A
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Background

Corn wet milling is an industrial process that fractionates corn kernels into their primary components: starch, protein, fiber, oil, and solubles (e.g., heavy steep water or corn steep liquor). The process begins with steeping, where kernels are soaked in a dilute sulfurous acid solution undergoing lactic acid fermentation. This step softens the kernels, facilitates downstream separations, and allows soluble components to diffuse out of the grain. The softened kernels then undergo a series of grinding and separation steps to recover the germ, from which oil is extracted, followed by separation of the fiber from the starch-protein (gluten) slurry. Finally, starch and gluten are separated based on their density differences, typically using centrifugation. The resulting streams—starch, corn protein, fiber, germ, and solubles—are the primary outputs of the corn wet mill and may be sold ‘as is’ or further processed into value-added products. 

 

A critical challenge in corn wet milling is the management of naturally occurring contaminants in corn, like mycotoxins. These compounds are largely unaffected by the initial processing steps and, due to their chemical properties, tend to concentrate in the non-starch co-product streams, primarily the corn protein meal (corn gluten meal) and related feed products. Current management relies heavily on raw material sourcing and testing, which provides a baseline level of control but does not eliminate the risk of contamination in the final co-products. 

 

In addition to existing quality control measures, there are significant opportunities to implement more advanced mycotoxin management strategies across both raw material sourcing and in-process operations to ensure final product safety and quality targets are consistently met. Innovation in this area could significantly improve co-product value and safety while supporting the production of high-quality, reliable ingredients for the feed and food industries.

What we're looking for

We are looking for manufacturing technologies, process innovations, and equipment solutions that improve the detection, management, and reduction of mycotoxins across the corn supply chain and wet milling process, from pre-harvest risk assessment and grain sourcing through in-process mitigation and final co-product quality assurance. Ideal solutions should generate clear quality assurance and risk-reduction outcomes, protect co-product value, and provide an attractive return on investment.

Solutions of interest include:
  • Pre-harvest predictive analytics leveraging field sensing, monitoring, or mycotoxin mapping data to support accurate risk mapping within the corn sourcing region surrounding a plant
  • Rapid mycotoxin screening capable of near real-time or yes/no detection around a threshold to trigger confirmatory quantitative test (exceeding the speed of conventional lateral flow tests)
  • High-throughput automated sorting technologies that physically remove contaminated kernels while minimizing loss of uninfected corn
  • Chemical, enzymatic, or other detoxification approaches capable of degrading mycotoxins into lower-toxicity or non-toxic compounds
Our must-have requirements are:
  • Targets aflatoxin, deoxynivalenol, zearalenone, and/or fumonisin
  • For physical separation approaches, solutions should minimize loss of uninfected corn and provide an estimate of expected uninfected grain loss
Our nice-to-have's are:
  • Solutions addressing additional mycotoxins such as ochratoxin or T-2 toxin
  • Global regulatory approval
  • Scalable and suitable for deployment in commercial corn supply chains or industrial-scale corn wet milling operations (100k to 400k bushels of corn per day)
What's out of scope:
  • Optical sorting of corn
  • Flotation-based separation of low-density infected kernels in a liquid medium
  • Non-scalable lab concepts
Acceptable technology readiness levels (TRL):
Levels 3-9
What we can offer you
Eligible partnership models:
Co-developmentLicensingSupply/purchase
Benefits:
Compensation
Budget is available to support proof-of-concept trials within pilot or commercial facilities, as well as co-development activities with R&D partners. Typical funding ranges from $50K to $300K, depending on the scope and applicability of the proposed technology. We are also open to licensing agreements or direct technology adoption for in-market solutions that demonstrate clear operational benefits.
Compounds and Reagents
Samples may be shared with selected partners to support validation or testing.
Data
Selected partners may receive access to relevant process data.
Facilities and Services
Visits to pilot or production facilities may be arranged following selection.
Who we are

Our global team includes more than 1,500 research, development, applications, technical services and intellectual property specialists working in more than 200 locations. Together, they provide a spectrum of services encompassing technical service, applications, development, research, intellectual asset management, and scientific and regulatory affairs.

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Reviewers
Q&A with Cargill

The Q&A is now closed.

Sort by:
Q.
Can you elaborate on the business requirement, why "exceeding the speed of conventional lateral flow tests" is important?
1
A.
Corn has to be graded at the site prior to being purchased, which can be 100 to several 100 trucks a day at a given site depending on its size. So, speed of testing is critical not to bottleneck corn receiving.
GP
Gene Peters, CSST High Performance Innovation R&D Lead, Cargill
May 12, 2026
Is this response helpful?
1
0
Q.
Hello, Does solutions to one or two mycotoxins still be considered a success for this project? Also what are the average concentrations of the individual mycotoxins in the wet mill or in the corn gluten meal? Thanks
1
A.
Yes, a technology that could impact a subset or single mycotoxin would still be relevant, particularly if it has low capital costs. Mycotoxins are an intermittent issue, in typical years at a given processing plant they are low, but in excursions mycotoxins can push the CGM and CGF/wet feed products or above regulatory limits. The US and EU regulatory limits around CGM and CGF can be used as ballpark concentrations of concern during a bad mycotoxin year for these two geographies.
GP
Gene Peters, CSST High Performance Innovation R&D Lead, Cargill
April 6, 2026
Is this response helpful?
0
0
A.
Thanks for your reply. Another question : what is an estimate of residence time in the process where the mycotoxins could be broken-down, sequestered, separated etc?? This will be an important parameter while testing possible solutions. Thanks.
1
A.
Sorry for the delay - It varies by process step, corn steeping runs 1-2 days, steps in the mill vary between minutes to seconds, to some points holding for up to a few hours.
GP
Gene Peters, CSST High Performance Innovation R&D Lead, Cargill
April 21, 2026
Is this response helpful?
0
0
Q.
How do you handle the indirect costs? Universities are charging 64% as indirect costs at this point for the for profit companies, do you comply with those guidelines or are their different rates that you go by?
1
A.
Sorry for the delay, I had to follow up with someone more experienced working with universities. Typically at that high of a rate of charge, where ~$1 of $3 is going to actual research, we would look to negotiate a lower rate.
GP
Gene Peters, CSST High Performance Innovation R&D Lead, Cargill
April 21, 2026
Is this response helpful?
0
0
Q.
Hello, I have two questions. The first is, will this be an internal monitoring test, or will this need to be approved by USDA FGS? The second, is the standard analytical range of 5 ppb - 300 ppb acceptable?
1
A.
Sorry for the delay - detection needs to correlate well with an approved test, but will be an internal test. Standard analytical ranges will vary by toxin, but the range stated would be useful for alfatoxin.
GP
Gene Peters, CSST High Performance Innovation R&D Lead, Cargill
April 21, 2026
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