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Herbicide novel compounds for grass weed control
  • Background
  • What we're looking for
  • What we can offer you
  • Who we are
  • Q&A
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Background

The majority of the most troublesome grass weeds have developed resistance to one, or more, of the most effective herbicides used for their control. The key weeds (Alopecurus, Avena, Setaria, Echinochloa, Phalaris or Lolium) have developed resistance to one or more herbicides from groups 1, 2, 3, 5, 9, 14 and 15, severely limiting grower options for controlling these weeds. Find descriptions of these herbicide groups here

 

There is an urgent need for a herbicide with a novel mode of action or site of action for control of grass weeds.

What we're looking for

We are looking for innovative solutions for the management of resistant grass weeds such as Alopecurus, Avena, Setaria, Echinochloa, Phalaris, and Lolium. Our goal is to identify compounds with a potential novel mode of action or site of action that display unique characteristics distinct from existing herbicides. We are also interested in partnering with experts who have developed screening models capable of identifying these new modes or sites of action. Potential partnerships include licensing or joint development.

Solutions of interest include:
  • Novel mode of action to control Alopecurus, Avena, Setaria, Echinochloa, Phalaris, Lolium not currently registered with the Herbicide Resistance Action Committee (HRAC)
  • Novel site of action for control of Alopecurus, Avena, Setaria, Echinochloa, Phalaris, Lolium
  • Novel screening platforms and models that can identify potential new herbicide modes or sites of action
  • Computational tools that can utilize genomics and metabolomics data to identify genes and pathways that could be targeted for herbicide development
Our must-have requirements are:
  • The eventual solution should be compatible with single application (herbicide should be effective after just one use per growing season)
  • Active on one or more annual grass weeds including Avena fatua, Alopecurus myosuroides, Echinochloa, Phalaris minor, Setaria viridis, Lolium rigidum
  • Preliminary data suggesting potential herbicide activity must exhibit distinct characteristics from current modes/sites of action
Our nice-to-have's are:
  • Whole plant assays demonstrating preliminary activity of tested compounds
  • Post-emergence application timing (solutions that can be applied after the target weeds have emerged from the soil)
  • Selectivity in one or more of the following grass crops - corn, cereals, rice
  • Systemic herbicides
Acceptable technology readiness levels (TRL):
Levels 3-9
What we can offer you
Eligible partnership models:
Co-developmentLicensingSponsored research
Benefits:
Sponsored Research
Funding is proposal dependent, but an accepted proposal may receive support in the range of 50,000 - 200,000 USD (milestone dependent) with the potential for follow on funding.
Expertise
Successful applicants will work with the UPL Global Lead for new Herbicide Technologies to manage the project.
Facilities and Services
Successful applicants will have access to UPLs global network of research stations and greenhouse/lab facilities to conduct research year-round.
Tools and Technologies
Available analytical capabilities include: • Active ingredient quantitation • In vitro/in vivo efficacy evaluation • Targeted biomarker quantitation • Oligonucleotide sequence verification and purity analysis • Untargeted metabolomics of biological products and tissues • Mode of action assays • Chemical synthesis • Chromatographic isolation, purification, identification of compounds of interest
Who we are

At UPL we are on a mission to Reimagine Sustainability for farmers and food systems – feeding the world while nurturing the planet. Each and every member of our team is making a difference – to our company’s growth, to our industry’s success, and to our sustainable food future. Our employees and teams reflect the diversity of our customers, the regions in which we operate, and the societies we serve.

 Learn more
Reviewers
Q&A with UPL

The Q&A is now closed.

Sort by:
Q.
Hello UPL Team, Will you consider a concept development project that may lead to experimental proof of concept within one or two years? My experience is based on in silico drug development for specific enzymes.
1
A.
Hi Zeno. Thanks for contacting us. It looks like your area of research is human health, specifically in the area of Type II diabetes. We would be focusing on plant metabolic pathways/enzymes and would require the ability to extract, isolate and analyze enzymes from these pathways so your systems/expertise may not be applicable. If you want to talk, drop me an email at arthur.yochim@upl-ltd.com. Thanks, Art
FE
Former Employee, Global Research Lead - Weeds, UPL
May 3, 2024
Is this response helpful?
0
0
Q.
Would target identification and mechanism of action studies of such a herbicide be appropriate for this request for proposals?
1
A.
Hi David. From your question it sounds like you have the ability to test for potential targets and to conduct studies to identify a mode of action of an existing compound. Ideally we are looking for someone to provide molecule(s) that have been confirmed to be active at a new site of action or that exhibit a new mode of action. It may be best to discuss in a telecon. If you email me at arthur.yochim@upl-ltd.com we can arrange a meeting. Thanks, Art
FE
Former Employee, Global Research Lead - Weeds, UPL
May 10, 2024
Is this response helpful?
0
0
Q.
Will you consider the delivery system for this herbicide application and RNAi technology? Or any interested herbicide for your target? We can make new nanoparticle formulation to enhance their efficiency.
1
A.
Hi Li - We would consider this delivery system, especially if it enables ultra-low volume applications. Please submit your proposal! We look forward to discussing further. Thanks, Art
FE
Former Employee, Global Research Lead - Weeds, UPL
May 20, 2024
Is this response helpful?
1
0
A.
Thanks Arthur for the encourage and I will submit the proposal. I am looking forward to talking with you about our approach.
1
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