Fungal pathogens pose a persistent challenge in both pharmaceutical and agricultural sectors, particularly as resistance to broad-spectrum fungicides continues to rise. Traditional fungicides, while effective, are increasingly met with resistance mechanisms that reduce their efficacy and longevity. This creates an urgent need for alternative strategies that can extend the utility of existing treatments.
Natural and synthetic-derived chemistries can be potentiators for fungicides. These compounds exhibit anti-fungal activity only in combination with a fungicide but have no fungicide activity alone. Furthermore, each potentiator increases the potency of its respective fungicide against its fungal target(s), by possibly improving the bioavailability of the fungicide to the pathogen, offering another mode of action, and extending the window of disease protection.
We are looking for potentiators that can provide the “second knockout punch” by improving the bioavailability of the fungicide, offering another mode of action, disabling a known resistance mechanism, and/or inhibiting cellular stress responses. Specifically, we want potentiators discovered through your chemical library screens combining sub-lethal doses of a fungicide against a laboratory fungal pathogen or a fungicide-resistant strain.
We want to collaborate with you to produce or synthesize these potentiator candidates and determine their efficacy combined with our proprietary fungicides, which fall within the chemistry and/or mode-of-action groups outlined below.
Shows no fungicide or toxic activity independently, only in combination with a fungicide
Reduces minimum inhibitory concentration of the fungicide in checkerboard assays
Mode-of-action can be predicted or defined
Can be detected and quantified using an analytical method
Non-toxic to human cell lines
Ability to supply a minimum of 10 mg of sample upon request
The Q&A is now closed.