Advanced LCMS and HPLC methods for mycotoxin analysis in grain extracts
Developed at Flinders University, this solution offers rapid, cost-effective LCMS and HPLC methods for detecting mycotoxins in grain extracts. Using advanced UHPLC and mass spectrometry techniques, it ensures precise identification and quantification, with potential adaptation to HPLC for high-concentration samples.
Overview
Flinders University has developed a cutting-edge solution for the detection and analysis of mycotoxins in grain extracts. Utilizing advanced liquid chromatography-mass spectrometry (LC-MS) and high-performance liquid chromatography (HPLC) methods, this technology ensures accurate identification and quantification of mycotoxins. The approach leverages ultra-high performance liquid chromatography (UHPLC) coupled with high-resolution mass spectrometry for precise analysis, making it an invaluable tool for agricultural and food safety sectors.
Technical specifications
- UHPLC-QTof and UHPLC-DAD-QQQ Systems: These systems provide high sensitivity and a large dynamic range for quantitative analysis, ensuring accurate detection of mycotoxins.
- Adaptability: The LC-MS methods can be adapted to more cost-effective HPLC techniques if the mycotoxin concentration is sufficient, offering flexibility and cost savings.
- Multiple Reaction Monitoring (MRM): This mode allows for enhanced detection limits and improved sensitivity, crucial for low-concentration mycotoxin analysis.
- Integration with commercial lateral flow devices: The validated method is compatible with widely used lateral-flow devices, facilitating efficient and widespread application.
Technology readiness level
This technology is at TRL 4, indicating that it has been validated in a laboratory environment and is ready for further development and field testing. The project includes milestones for optimization and validation to ensure robust performance in real-world applications.
About Flinders University
Flinders University is a comprehensive public research university based in Adelaide with a growing footprint across South Australia. Its Tonsley campus sits inside the Tonsley Innovation District, placing researchers alongside industry, government, and startups in facilities designed for co-development and demonstration. The health and medical precinct integrates the university with Flinders Medical Centre and a new Health & Medical Research Building, enabling rapid clinical collaboration and translation. Research is supported by competitive funding from the Australian Research Council, the National Health and Medical Research Council, and the Medical Research Future Fund. A dedicated research partnerships and commercialisation team and an active entrepreneurship institute help industry engage, manage IP, and launch new ventures.
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