Arginine-prebiotic-postbiotic synergy for gingival homeostasis

Overview

This innovative solution offers a comprehensive approach to oral care by utilizing a synergy of L-Arginine, Xylo-oligosaccharides (XOS), and a Lactobacillus ferment lysate. Together, these components work to maintain gingival homeostasis through a triple-action mechanism. The technology targets the ecological drivers of gingival dysbiosis, promoting beneficial commensals that reverse low-pH environments, inhibiting pathogen adhesion, and modulating inflammatory responses, thus maintaining a healthy oral microbiome.

Technical specifications

Key features:

• L-Arginine: Acts as a metabolic prebiotic, enhancing the Arginine Deiminase System (ADS) to produce ammonia, which neutralizes acidic conditions.
• Xylo-oligosaccharides (XOS): Serves as a structural prebiotic, selectively fermented by beneficial bacteria, creating a competitive environment against pathogens.
• Lactobacillus ferment lysate: Provides bioactive postbiotics, including peptidoglycans and exopolysaccharides, to block pathogen adhesion and modulate cytokine signaling.

The technology effectively balances oral ecology with a shelf-stable formulation, suitable for incorporation into consumer oral care products like mouthwash.

Technology readiness level

Currently at TRL 4, this technology has demonstrated potential in laboratory settings with ongoing plans for further validation through sponsored research. The next phase includes formulating a synbiotic mouthwash to test efficacy and stability, ensuring the active ingredients remain effective and consumer-friendly.