Arginine-Prebiotic-Postbiotic synergy for gingival homeostasis
A novel triple-action oral care technology combining L-Arginine, Xylo-oligosaccharides, and Lactobacillus ferment lysate to enhance gingival health by neutralizing acidic environments, inhibiting pathogen adhesion, and modulating inflammation.
Overview
This innovative solution offers a comprehensive approach to oral care by utilizing a synergy of L-Arginine, Xylo-oligosaccharides (XOS), and a Lactobacillus ferment lysate. Together, these components work to maintain gingival homeostasis through a triple-action mechanism. The technology targets the ecological drivers of gingival dysbiosis, promoting beneficial commensals that reverse low-pH environments, inhibiting pathogen adhesion, and modulating inflammatory responses, thus maintaining a healthy oral microbiome.
Technical specifications
Key features:
- L-Arginine: Acts as a metabolic prebiotic, enhancing the Arginine Deiminase System (ADS) to produce ammonia, which neutralizes acidic conditions.
- Xylo-oligosaccharides (XOS): Serves as a structural prebiotic, selectively fermented by beneficial bacteria, creating a competitive environment against pathogens.
- Lactobacillus ferment lysate: Provides bioactive postbiotics, including peptidoglycans and exopolysaccharides, to block pathogen adhesion and modulate cytokine signaling.
The technology effectively balances oral ecology with a shelf-stable formulation, suitable for incorporation into consumer oral care products like mouthwash.
Technology readiness level
Currently at TRL 4, this technology has demonstrated potential in laboratory settings with ongoing plans for further validation through sponsored research. The next phase includes formulating a synbiotic mouthwash to test efficacy and stability, ensuring the active ingredients remain effective and consumer-friendly.
About Indonesia International Institute for Life Sciences
i3L University, formerly Indonesia International Institute for Life Sciences, is a young, compact private research university in Jakarta with an interdisciplinary and globally connected character. Its laboratory environment gives corporate partners access to analytical testing, research support, and practical collaboration through the i3L Analysis Center. The university builds joint R&D and workforce-development relationships with industry, government, communities, and international academic partners, supported by executive training and professional upskilling. Research is supported by competitive Indonesian national funding, internal grants, and selected international or industry-backed awards, including programs associated with the Ministry of Education and BRIN. A research and community-service office helps coordinate external collaboration and knowledge transfer.
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