Ebselen analogs as novel fungicides targeting fungal autophagy in rice blast
Innovative fungicides, ebselen and its analogs, inhibit fungal autophagy to control rice blast disease. These compounds target Atg4 cysteine protease, disrupting pathogenic processes. Validated in vitro and in planta, they offer a safe, sustainable solution for rice protection.
Overview
Ebselen and its analogs represent an approach to combating rice blast disease. By targeting the autophagy pathway in the rice blast fungus Magnaporthe oryzae, specifically inhibiting the Atg4 cysteine protease, these compounds disrupt appressorium formation, an essential step for fungal infection. This selective inhibition is intended to provide a method to protect rice crops while avoiding adverse effects on plant health, as an alternative to conventional fungicides.
Technical specifications
Using a Bioluminescence Resonance Energy Transfer (BRET)-based high-throughput screening platform, researchers have identified ebselen and its analogs as potent inhibitors of Atg4-mediated Atg8 cleavage. These compounds have been validated through in vitro and in planta assays, supporting their ability to block fungal infection. Structure-based modeling is also used to improve screening precision and support species-specific targeting of fungal Atg4. The program notes a human safety profile for ebselen, positioning the series for optimization in formulation and field applications.
Technology readiness level
Currently at Technology Readiness Level 4, the work is in the validation and optimization phase. Next steps include refinement for formulation, further validation of safety and selectivity, and regulatory assessments. Planned activities include greenhouse and small-scale field trials, followed by a pilot market launch to gather end-user feedback and guide further development.
About University of Wyoming
A comprehensive public land‑grant university serving Wyoming from its Laramie campus and regional sites. Industry engages through co‑located high‑bay and pilot‑scale facilities, field stations across the state, and an incubator network that provides mentorship and startup space. A partnership with a national supercomputing center in Cheyenne enables advanced modeling, visualization, and large‑dataset workflows, while the extension network connects companies to talent and end users in every county. Research is supported by competitive federal funding from agencies such as NSF, DOE, USDA, and NIH, alongside state and industry collaboration. A dedicated technology transfer office advises on IP, licensing, and commercialization.
delivered to your inbox.