Encapsulation of probiotics using modified high DM, low MW pectin
A novel encapsulation technology using modified citrus pectin with high degree of methylation and low molecular weight to protect probiotics during processing and digestion, ensuring delivery to the gut. This technology enhances stability in beverages and acts as a potential prebiotic.
Overview
This innovative technology focuses on the encapsulation of probiotics using a modified citrus pectin. The pectin has a high degree of methylation (DM >90%) and a low molecular weight (MW 10,000-20,000 Da), allowing for improved solubility in liquid foods. It aims to protect probiotics during beverage processing and throughout the digestive journey, ensuring probiotics reach the gut intact. Additionally, the pectin serves as a potential prebiotic, supporting gut health by being degradable by gut microorganisms.
Technical specifications
- High DM and Low MW Pectin: The pectin's high DM enhances hydrophobic interactions, enabling the formation of fine nano-encapsulates (300-400 nm) without protein co-emulsifiers.
- Robust Stability: The encapsulation is designed to withstand high-temperature short-time (HTST) processing and resist digestive enzymes and stomach acidity.
- Prebiotic Potential: As a dietary fiber, it is non-digestible by humans but can foster beneficial gut microorganisms.
- Previous Validation: Published studies have demonstrated its effectiveness in forming stable emulsions and delivering tributyrin to the gut.
Technology readiness level
Currently at TRL 4, this technology has been validated in lab settings, with several studies published. Future validations are planned to optimize encapsule preparation, enhance solubility and stability, and test probiotic release under simulated digestive conditions.
About Jiangnan University
Jiangnan University is a comprehensive public research university in Wuxi, China, known for a research-driven, industry-engaged character. State-level research platforms are co-located with pilot-scale facilities that support process development and scale-up, enabling direct collaboration with enterprises on applied R&D and technical services. A university science park, joint research institutes with regional governments, and a National Technology Transfer Center provide structured on-ramps for co-development, sponsored research, and rapid deployment. Research is supported by competitive national and provincial programs, including the National Natural Science Foundation of China and the Ministry of Science and Technology’s National Key R&D Program. Clinical partners through the university’s affiliated hospital extend capabilities into translational and human-centered studies.
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