Eutectic formulations for aroma stability and release

Overview

Natural deep eutectic systems (NADES) are proposed as effective excipients for topical cough suppressant formulations, offering enhanced aroma stability and controlled scent release. These systems utilize a hydrogen-bonding network to create a stable, homogeneous liquid mixture that solubilizes bioactive volatile compounds, reduces evaporation, and improves fragrance performance. The use of NADES not only ensures a stable formation but also enhances the sensory experience by improving skin feel and promoting consistent spreading.

Technical specifications

NADES are characterized by their ability to act as solvents and stabilization matrices for volatile compounds. Their supramolecular liquid environment modulates molecular mobility, decreases vapor pressure, and limits oxidation and evaporation. Key features include:

• High load capacity for scent actives
• Tuneable viscosity
• Compatibility with aqueous and lipid-based formulations
• Ability to maintain chemical composition and antioxidant activity of volatile extracts for extended periods
• Preparation from biocompatible constituents

Technology readiness level

Currently, the technology is at TRL 4, having been validated to maintain chemical composition and antioxidant activity for at least six months under ambient conditions. The next steps involve optimizing formulation stability, compatibility, and sensory properties, followed by scale-up analysis for potential commercial translation.