Ion-chromatography-mass spectrometry method for mycotoxin analysis
A novel IC-MS method to quantitatively analyze highly polar and ionic mycotoxins in corn and wheat, leveraging advanced ion-chromatography and mass spectrometry for improved detection of challenging mycotoxins.
Overview
This research focuses on developing an innovative ion-chromatography-mass spectrometry (IC-MS) method designed to quantitatively analyze a wide range of highly polar and ionic mycotoxins present in corn and wheat. The method aims to overcome the limitations of conventional LC-MS approaches, providing enhanced detection capabilities for analytically challenging mycotoxins that are critical to the food and agricultural industries.
Technical specifications
Key features:
- Utilizes IC-MS, known for its efficacy in analyzing carboxylated and multi-carboxylated compounds.
- Targets mycotoxins such as Ochratoxin A, HT-2 toxin, and Citrinin fumosins, which are difficult to detect with standard methods.
- Includes development of optimized extraction procedures for corn and wheat samples.
- Focuses on key validation parameters, including sensitivity, linearity, and recovery.
Technology readiness level
Currently at Technology Readiness Level 2, this method is in the development phase, with plans for validation using authentic corn and wheat samples. The research team aims to complete the development and validation process within one year.
About University of Oxford
The University of Oxford is a comprehensive collegiate research university in the UK, pairing wide academic breadth with intensive research and innovation. Industry engages through the university-owned Begbroke Science Park, which co-locates laboratories with high-growth companies, and via proximity to the Harwell Science and Innovation Campus with national facilities such as Diamond Light Source. Clinical translation is enabled by a partnership with Oxford University Hospitals through an NIHR Biomedical Research Centre. Research is supported by UK Research and Innovation councils and the National Institute for Health and Care Research, alongside major charities. Technology transfer and corporate engagement are managed by Oxford University Innovation, which handles IP, licensing, consultancy and spinouts.
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