Non-animal collagen and collagen-supporting protein production using pichia pastoris
BioGrammatics offers engineered Pichia pastoris strains for producing non-animal collagen and collagen-supporting proteins. With over 100 years of combined expertise in recombinant protein production, the company leverages its proprietary Pichia tools to develop custom production strains for applications ranging from food ingredients to biomedical materials.
Overview
BioGrammatics offers a protein production platform based on the methylotrophic yeast Pichia pastoris for generating collagen and collagen-supporting proteins of non-animal origin. Pichia pastoris enjoys GRAS (Generally Recognized As Safe) classification and is already used in products consumed by humans, including protein supplements and heme proteins incorporated into food products. This platform addresses the growing market demand for animal-free collagen across food, cosmetics, and biomedical applications.
Technical specifications
Key features:
- Proprietary Pichia expression vectors and competent yeast strains designed for efficient heterologous gene expression
- Custom strain construction tailored to produce specific collagen types or collagen-supporting proteins
- Production of collagen derivatives, including gelatins
- Non-animal origin production process suitable for human-consumed products
- Combined expertise of over 100 years of recombinant protein production with Pichia
Technology readiness level
The production of collagen and collagen derivatives in Pichia pastoris is well established in the scientific literature. BioGrammatics is currently engineering a new set of production strains using its proprietary Pichia tools. Standard strain construction and expression testing are offered to validate and produce the specific type of collagen or collagen-supporting proteins required for each application.
About BioGrammatics
BioGrammatics, Inc. is a biotechnology company established in 2008 that specializes in Pichia pastoris protein expression systems. The company provides a comprehensive suite of products and contract services designed to facilitate heterologous gene expression. Their offerings include proprietary expression vectors, competent yeast strains, selection media, and specialized kits, alongside expert support services such as custom strain construction, gene optimization, transcriptome generation, and genome sequencing. By leveraging their expertise in the methylotrophic yeast Pichia pastoris, BioGrammatics aims to provide innovative tools that simplify and improve the efficiency of protein development.
These solutions serve a diverse range of clients across academic, industrial, and regulatory sectors, assisting with projects ranging from basic research on inhibitors to the production of industrial flavorings. The company's capabilities allow them to support customers throughout the entire development lifecycle, from initial vector construction to the generation of genomic data required for regulatory submissions. Based in Carlsbad, California, BioGrammatics functions as a research-focused partner that helps organizations solve complex protein expression challenges, ensuring their customers can achieve success in their laboratory and commercial development efforts.
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