Plant-based peptide hydrolysate that inhibits hyaluronidase and collagenase (MMP): seeking clinical co-development partner for joint and skin health

VELOZBIO is seeking a partner to co-develop the clinical validation of a plant-based peptide hydrolysate for joint health and beauty-from-within. We handle the full production process; we are looking for a partner to design and run human studies that confirm its bioactivity.

WHAT IT IS A hydrolysate from a well known pulse protein, enriched in peptides that inhibit two enzymes responsible for breaking down the extracellular matrix:

• Hyaluronidase, which degrades hyaluronic acid (HA) in synovial fluid and skin
• Collagenase (MMP), which degrades collagen in cartilage and the dermis One plant-based ingredient that helps preserve both HA and collagen, instead of only supplementing them.

WHY IT MATTERS Joint and skin ingredients are dominated by animal-derived collagen (bovine, porcine, marine), and most work by adding building blocks rather than protecting what the body already has. A protective, plant-based, non-GMO ingredient from a well known pulse, which is not a major allergen in the US or EU, fits vegan, halal/kosher and clean-label formulations in supplements, functional beverages and nutricosmetics.

HOW IT WORKS Our AI-guided discovery platform identifies candidate bioactive sequences. We then select enzymes and downstream processing conditions, including filtration, to produce those peptides.

PROOF TO DATE

• Hyaluronidase and collagenase (MMP) inhibition demonstrated in in silico.
• In-house production of the base protein and the hydrolysate at our facility, with an active US distribution agreement for the base ingredient

WHAT WE BRING

• Protein extraction, enzymatic hydrolysis, filtration and enrichment, done entirely in-house
• Study material in the required quantities, with Certificate of Analysis per lot
• In vitro bioactivity data and technical support for study design
• Scale in production and competitive costs.

WHAT WE ARE LOOKING FOR A partner to co-develop the clinical program, such as a CRO, an academic clinical research center, or an ingredient or brand company willing to co-invest:

• Clinical study design: endpoints, dose and duration
• Human trials for joint comfort and mobility and/or skin firmness, elasticity and hydration
• Biomarker analysis related to HA and collagen turnover
• Support for structure/function claims and regulatory dossiers

NEXT STEPS

1. Agree on the study design and target claims
2. Run a pilot human study with VELOZBIO-supplied material
3. Scale to a confirmatory study if results support it
4. Launch as a branded ingredient with clinically backed claims

We are open to co-development with cost sharing, publication rights and preferential access for the partner, such as first right to supply or field-of-use exclusivity. Contact us to discuss data under NDA.