R.V. College of Engineering

Microbial Biopesticide and Plant Probiotic Solutions for Enhanced Crop Yield and Soil Health

A metagenomics-based approach to identify and validate naturally occurring microbes that act as both biopesticides and crop growth promoters. Targets commercially important crops such as wheat, maize, rice, peanut, and s...

Novel thiole di-oxide derivative targeting LAMP-1 for PET imaging of lysosomal storage diseases

Computationally designed small molecule ligand that binds LAMP-1, a key lysosomal membrane protein. Developed through pharmacophore modeling and screening of 19M synthetic compounds, the lead candidate shows strong Caco-...

Integrative In-Silico Screening for SGLT1 and GLUT5 Modulators

Computational screening platform that identifies and ranks potential inhibitors and activators of SGLT1 and GLUT5 glucose and fructose transporters. Combines molecular docking, pharmacophore modeling, machine learning, a...

Novel nutritional formulation for telomere stability and healthy aging

A GRAS-safe oral supplement combining Astragalus membranaceus with vitamin D and omega-3 fatty acids, designed to support optimal telomere maintenance and promote healthy aging. Developed through computational screening ...

Targeted small molecule strategy against collagen α-3(IV) for anti-GBM disease

A computational drug discovery approach identifying natural small molecules that bind collagen alpha-3(IV) to block autoantibody interactions in Goodpasture syndrome. The strategy aims to halt the immune cascade causing ...

Targeting novel metacaspase effector to develop antifungal strategies against Rhizoctonia solani

Genome-wide identification of seven novel effectors in Rhizoctonia solani, a major rice pathogen, with focus on RS107_6, a metacaspase protein. This research enables design of novel antifungal compounds by targeting effe...

Benzoxadiazole Derivatives as TAL Effector Antagonists for Rice Bacterial Blight Control

In silico-validated library of benzoxadiazole derivatives designed to block TAL effector (PthXo1) binding to rice DNA, offering a novel small-molecule strategy to prevent Xanthomonas oryzae bacterial blight in rice crops...

Ethylhexylglycerin as a Safe and Eco-Friendly Alternative to Isothiazolinone Preservatives in All-Purpose Cleaners

A research initiative exploring Ethylhexylglycerin as a safer, more stable, and biodegradable alternative to Isothiazolinone-based preservatives in all-purpose cleaning products. The project aims to validate its antimicr...

Computationally Designed AOPP Herbicide Compounds Targeting Echinochloa with Improved Selectivity and Safety

Novel herbicide candidates designed using a cyhalofop-butyl pharmacophore template and validated through molecular docking, MD simulations, and in-silico safety profiling. The compounds target acetyl-CoA carboxylase in b...

Succinate dehydrogenase inhibitors for Fusarium head blight control

Computationally identified milbemycin-class fungicide actives targeting Fusarium graminearum succinate dehydrogenase to control Fusarium head blight disease, with potential dual anti-fungal and anti-bacterial activity.