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Formulations and solutions for recurrent vaginal yeast infections
  • Background
  • What we're looking for
  • What we can offer you
  • Who we are
  • Q&A
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Background

Bayer is seeking solutions in the field of intimate health for their Canesten brand, where cutting-edge science meets soothing relief for everyday skin and intimate health needs. 

 

Recurrent vaginal yeast infections (VYI) represent a common challenge affecting numerous women worldwide, typically characterized by three or more vulvovaginal candidiasis (VVC) episodes annually.  

 

These infections stem primarily from an overgrowth of Candida, a naturally occurring yeast in the body. Disruptions in the body's microbiome, often triggered by factors like antibiotics, hormonal fluctuations, or a compromised immune system, can precipitate this overgrowth.  

 

The repercussions for the individual can be substantial, as symptoms such as vulval itching, burning, and discharge result in discomfort and distress. Seeking treatment often involves OTC antifungal medications or prescribed drugs.  

 

Seeking treatment often involves over-the-counter (OTC) antifungal medications or prescribed drugs. Misuse and overuse of antifungal and antibacterial medications can lead to drug-resistant strains of Candida, complicating the treatment of yeast infections and exacerbating the issue of antimicrobial resistance in other bacterial and fungal infections.

What we're looking for

We are looking for novel technologies/formulations targeting vaginal yeast infections. This could be via improving formulations containing clotrimazole or through other, novel means. We seek a solution that treats the infection itself, rather than solutions applied cosmetically that solely address the symptoms of itchiness and discomfort. Solutions of interest include, but are not limited to, the following.

Solutions of interest include:
  • Additives/adjuvants to clotrimazole
  • Biofilm disruption technologies
  • Recurrent vaginal yeast infection (VYI) treatment
  • Antibiotic/antifungal solutions with new mode of action limiting recurrence
Our must-have requirements are:
  • We are ideally seeking a solution that can take a non-prescription approach, such as OTC (over the counter) or medical device
Our nice-to-have's are:
  • We are open to all stages of development, with priority given to the clinical phase and solutions that are near the commercial stage
  • Topical solutions that act directly within the intimate area are preferred versus systemic treatments (such as oral medications) that work through a body-wide approach
What's out of scope:
  • Any brand new active pharmaceutical ingredient (API) that would require a prescription
  • Cosmetic-only solutions such as soothing gels, anti-itch and creams, washes, moisturizers, deodorants and intimate wipes, that offer only temporary symptom relief
Acceptable technology readiness levels (TRL):
Levels 5-9
What we can offer you
Eligible partnership models:
Co-developmentSupply/purchaseLicensing
Benefits:
Expertise
-Partners will have access to industry experts in formulation development, regulatory affairs, clinical affairs and project management, offering specialized knowledge & insights to drive innovation forward. -Partners will benefit from a robust network of experts, labs, and Contract Manufacturing Organizations, fostering collaboration &resource accessibility for a successful Co-Development journey.
Who we are

At Bayer, our mission is to use science to improve everyday health for everyone. We can’t do it alone, so we actively search for and bring in talented, driven partners from around the consumer health industry. With our size and scale, we can help bring exciting new tools developed by others to market faster, and increase people’s access to them.

Our commitment to partnerships means simply bringing better products to those who need them faster. We look for partners who have new ideas, capabilities, insights and strengths that we might not have. For our partners, this commitment can mean access to much-needed investment or technical capacity. But most importantly, it means knowing they are working with a science-led and trusted global company that can help them grow and reach more people.

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Reviewers
Q&A with Bayer Consumer Health

The Q&A is now closed.

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Q.
Recently we have found some natural biofilm disruptors and nanotechnology-based solutions, but for other indications. A combination product can be developed, keeping your drug. Will it work for you?
2
Q.
Dear Sponsor, Could you please clarify whether drugs that are currently approved as prescription medications, but which have the potential for approval for over-the-counter (OTC) use are eligible for this RFP? The majority of OTC drugs are initially approved as prescriptions, then receive OTC approval. I am also confused by the wording stating that "We are ideally seeking a solution that can take a non-prescription approach" and later listing prescription approaches as out-of-scope. The former suggests prescription approaches may be pursued, even though they are not ideal, while the latter suggests they would not be pursued. Could you please clarify? Thank you, Sincerely, Alexander Novokhodko
1
A.
Hi - thank you for your great question. Actually we could explore ideas coming from the Rx world if the switch is likely to be successful (because of clinical background etc.), but brand new molecules with no real-world clinical data are not 'switchable' to OTC short-terms, so are out-of-scope. Hope that helps clarify. Thanks a lot for your interest and help! :)
FD
Florence Dupasquier, EI&P lead, Bayer Consumer Health
May 13, 2024
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