Encapsulation of hydrophobic compounds using cyclodextrins and spray drying
Innovative encapsulation method leveraging cyclodextrins and spray drying for effective encapsulation of hydrophobic compounds. This approach offers a cost-effective and scalable solution using biodegradable materials, ideal for pharmaceuticals, food, and cosmetics.
Overview
This innovative encapsulation technology utilizes cyclodextrins (CDs) and a spray drying process to effectively encapsulate hydrophobic compounds. The unique molecular structure of CDs—comprising a hydrophobic interior cavity and a hydrophilic exterior—facilitates the formation of inclusion complexes with hydrophobic substances. This method is cost-effective and energy-efficient. Additionally, the spray drying technique employs maltodextrin and gum arabic as wall materials to create core-shell microcapsules, which are biodegradable and biobased, ensuring sustainability.
Technical specifications
- Cyclodextrins (CDs): Available in three forms (α, β, γ), these oligosaccharides are completely soluble in water. Encapsulation involves dissolving CDs in water, adding hydrophobic compounds, and forming inclusion complexes through homogenization and separation by filtration.
- Spray drying: Utilizes maltodextrin and gum arabic, dissolved in water, with the addition of a surfactant (Tween 80). The process includes homogenization, emulsion formation, and drying at specific conditions (inlet temperature of 140 °C, feed rate of 120 mL h−1).
Technology readiness level
This solution is at Technology Readiness Level 4, indicating that it has been validated in a laboratory environment and is progressing towards further validation and potential commercialization.
About University of Novi Sad
The University of Novi Sad is a comprehensive public research university and one of the largest in Serbia, combining broad academic breadth with an applied research culture. Industry engagement is enabled by co‑located labs and a research and technology park that links faculty, students, startups, and corporate tenants. Integration with a major teaching hospital supports clinical studies and translational collaborations, while proximity to a dynamic regional ICT and agri‑food economy provides ready access to talent and pilot environments. Research is supported by competitive European programs and national funding, alongside industry‑sponsored contracts. A dedicated technology transfer office manages IP, licensing, and startup formation, with liaison services that streamline collaboration agreements.
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