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Novel actives for insect and nematode control
  • Background
  • What we're looking for
  • What we can offer you
  • Who we are
  • Q&A
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Background

Resistance development in pest populations, both to conventional chemical pesticides and to pest control traits in genetically modified crops, poses a significant challenge to sustainable agricultural production worldwide. This resistance limits the effectiveness of existing tools and reduces the available options for growers, making crop protection increasingly difficult and costly. There is a critical need for novel, effective, and durable biological or chemical solutions to manage these evolving threats.

What we're looking for

We are looking for the next generation of active ingredients, proteins, and RNA-based molecules to control economically significant agricultural pests, including insects and plant-parasitic nematodes. Pesticidal compounds of interest include (1) biochemical molecules such as proteins, peptides, and RNA or other macromolecules appropriate for in planta production and (2) chemical compounds, also referred to as small molecules. Such compounds may be derived from bacteria, archaea, fungi, protists, algae, and plants. We welcome both naturally occurring compounds and engineered or derived variants. Actives of high interest will be considered for licensing agreements. Finalists may be asked to sign a material transfer agreement and ship their actives for internal evaluation, at BASF’s expense. Solutions of interest include new pesticidal compounds exhibiting significant activity against the following pest groups:

Solutions of interest include:
  • Lepidopteran insects such as armyworms, diamondback moths, and bollworms
  • Coleopteran insects such as beetles, rootworms, and weevils
  • Hemipteran insects such as stink bugs, planthoppers, leafhoppers, and thrips
  • Plant-parasitic nematodes such as root-knot nematodes (RKN), root lesion nematodes (RLN), and soybean cyst nematodes (SCN)
Our must-have requirements are:
  • Shows preliminary evidence of pesticidal activity against target pest(s)
  • Suitable for either in-plant expression or crop protection applications (e.g., foliar, soil, or seed treatment)
  • Novelty may be indicated by difference in sequence or structure relative to known compounds
Our nice-to-have's are:
  • Active exhibits significant activity towards resistant populations of the target pest(s)
  • Data suggesting a new site of action or mode of action
  • Data indicating low or limited toxicity to beneficial organisms
What's out of scope:
  • Actives derived from vertebrate sources
  • Metabolic engineering of model or crop plants to produce metabolites with pesticidal activity
  • Genetically-engineered or gene-edited insects for use in biological or genetic control strategies
Acceptable technology readiness levels (TRL):
Levels 3-4
What we can offer you
Eligible partnership models:
Sponsored researchCo-developmentLicensing
Benefits:
Sponsored Research
Authors of selected proposals will be contacted by BASF to discuss the structure and scale of a potential collaboration. The type of collaboration will be dependent on the proposal and can comprise funded research, co-development, and/or IP licensing.
Expertise
The authors of every selected proposal will communicate directly with (a) BASF scientist(s) who will provide guidance and feedback on the project.
Who we are

As a global chemical company, we operate in diverse markets with varying requirements. To ensure responsible conduct and maintain our license to operate, we are guided by our core values and standards. These values shape our daily actions and foster respectful relationships with colleagues, customers, and partners.

Our teams are committed to putting health and safety first, making sustainability a part of every decision, and meeting strict compliance and environmental standards. We embrace diversity—in people, perspectives, and experiences—and promote open feedback grounded in honesty, respect, and trust. We see setbacks as opportunities to learn and improve.

 Learn more
Reviewers
Q&A with BASF

The Q&A is now closed.

Sort by:
Q.
Does this exclusion apply only to transgenics producing these metabolites in the field, or also to transient expression systems used to generate and extract these metabolites as purified actives for formulation?
1
A.
out of scope is transgenic plants, producing the metabolites, as a commercial product; expression systems needed to produce these metabolites which are then formulated as a sprayable application is in scope
JR
Jeroen Van Rie, senior principal scientist, BASF
October 27, 2025
Is this response helpful?
2
0
Q.
Are compounds of this publication of interest? New derivatives of benzhydroxamic acid with nematocidal activity against Haemonchus contortus and Caenorhabditis elegans. doi.org/10.1016/j.ijpddr.2025.100599
1
A.
Hello Thomas, Yes, compounds from this publication would be interesting to us. Would you please submit a proposal for us to review?
BS
Breann Summerall, Research Development Manager, BASF
October 27, 2025
Is this response helpful?
1
0
Q.
An extract with 80–90% nematicidal activity against root-knot nematodes; the active compound has not yet been identified or characterized. Is such an early-stage extract eligible, or do you require characterized actives?
1
A.
Hello Rocio, An extract such as this could be interesting for us, even if not fully characterized.
BS
Breann Summerall, Research Development Manager, BASF
October 27, 2025
Is this response helpful?
1
0
Q.
In an earlier study,we demonstrated that electrochemically generated ozonated water has the potential to reduce nematode problems in horticulture doi.org/10.1007/s41348-021-00524-0. Is this topic also of interest to you?
1
A.
Hello Frank, Thank you for your question. This is an interesting result, however it falls outside of the scope of this project.
BS
Breann Summerall, Research Development Manager, BASF
November 21, 2025
Is this response helpful?
0
0
Q.
Would you consider an in-plant expression of a strong nematocidal and pesticidal natural compound?
1
Q.
Hello Breann. Please have a look at our publication and let me know if the protein in this publication is of interest. https://doi.org/10.1111/pbi.13989 thanks
1
A.
Dear Harsh, thanks for reaching out. Trypsin inhibitors fall outside of our scope of interest.
JR
Jeroen Van Rie, senior principal scientist, BASF
November 5, 2025
Is this response helpful?
0
0
Q.
new bacteria very agressive on fly https://www.researchgate.net/profile/Kallel-Sadreddine
1
Q.
Plastomics has efficacious insect resistance traits in our transgenic soybean chloroplast pipeline. Events need to be introgressed into commercial germplasm for field testing. Should we propose a collaboration?
1
A.
Depending on the target species of the traits we may have an interest. So yes, please submit your proposal.
JR
Jeroen Van Rie, senior principal scientist, BASF
November 5, 2025
Is this response helpful?
0
0
Q.
We developed a bioproduct that traps nematodes with dual action on animal and plant pests. We seek industrial partners to collaborate in scaling and commercialization.
1
A.
Assuming the bioproduct you are referring to are nematophageous fungi: At this time we would not be interested due to compatibility challenges of nematophageous fungi with fungicide use in agriculture. Please let us know if we've made a faulty assumption or if you have other technologies to consider. Many thanks.
BS
Breann Summerall, Research Development Manager, BASF
October 13, 2025
Is this response helpful?
0
0
Q.
Are bio-based terpenoids of interest? We have developed a microbial platform for terpenoids production. You can find information about one of our compounds here. " https://msut.technologypublisher.com/technology/43029"
1
Q.
Hi, A botanical pesticide (derived from GRAS herb) has novel systemic action (applied to roots) against Lepidopteran and Hemipteran pests It has been independently validated in field conditions. Would you be interested?
1
A.
Hello, thank you for your question. Yes, we would be interested in learning more. Would you please submit a proposal for our review?
BS
Breann Summerall, Research Development Manager, BASF
October 13, 2025
Is this response helpful?
1
0
Q.
We have been working on a wheat antifungal protein extracted from transiently expressed in tobacco leaves that showed broad spectrum activity against several plant pathogens. We will test this protein against RKN soon. Is our work eligible for submitting our proposal?
1
Q.
Hi, please review our publication about Spotted-wing drosophila repellants from anthracnose-infected fruit and let us know if this is of interest. https://doi.org/10.1002/ps.7692
DL
Donghyun (sean) Lim, , Rutgers University
November 17, 2025
1
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