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- What we can offer you
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Background
Mycotoxins are naturally occurring toxins produced by certain molds (fungi) and can be found in food. There are thus common food safety tests that look for mycotoxins.
In food testing, the most reliable or preferred method for detecting small molecules is called paired sample testing.
In paired sample testing for foods (such as grains), the extracted sample is first tested using the HPLC/LC-MS method. In these methods, extractions can contain analytes which target a family or group of mycotoxins or other targets of interest. Later, the sample undergoes immunodiagnostic tests. The results are averaged from the two tests.
What we're looking for
We are looking to create HPLC/LC-MS method or equivalent test using extractions that are paired with commercially available lateral flow devices. A strong collaborator would have experience in developing HPLC or LC-MS methods to assist us in analytical methods detecting mycotoxins from organic extraction solutions.
Solutions of interest include:
- Testing methods or protocols for detecting mycotoxins through HPLC
- Testing methods or protocols for detecting mycotoxins through LC-MS
Our must-have requirements are:
- Must be either an HPLC or LC-MS method.
- Must be able to quantitatively detect mycotoxins in grain extracts using standard extraction solutions.
What's out of scope:
- Grain extracts not using corn or wheat as part of the matrix.
- Immunodiagnostic tests
Acceptable technology readiness levels (TRL):
Levels 3-9
What we can offer you
Eligible partnership models:
Sponsored researchGift/awardCo-developmentLicensingSupply/purchase
Benefits:
Sponsored Research
We are able to partner with entities that meet our TRL requirement but aren't yet ready for commercialization via sponsored research up to $100,000Gift/award
For institutions that are able to receive gifts, we are enabled to provide support in the form of a gift of up to $100,000 for this research.Expertise
We have hundreds of years of combined expertise in this space and can share historical knowledge with a partner under NDA.Tools and Technologies
In-Kind Analytical instrumentation and expertiseCompounds and Reagents
We have standard reference materials as well as experimental materials that can be shared.Data
Data analysis and generation in-kindFacilities and Services
We have internal analytical laboratories that can be leveraged for this work.Who we are
We believe we’re all in this together. Our partnerships with universities and other organizations — some new, some decades-long — make us and our industries stronger. Our company was born in 1982 of collaboration between academic innovations coming from Michigan State University and industry partners, and that theme has carried us into today.
Some of our most valuable partnerships have led to technological innovations that have benefitted food and animal safety on a large scale, like our 20+ years of work with the University of Nebraska’s Food Allergy Research and Resource Program. We work with representatives from many spheres — academic, public and private — to use research to strengthen our industries together.
Learn moreReviewers
AS
Adam Stanenas
R&D Director - Product Engineering
DA
Dave Almy
Senior Director of R&D
Q&A with Neogen Corporation
The Q&A is now closed.
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Q.
Do we need to extract the grain or do we get the grain extracts that are used for mycotoxin detection? If we should prepare the extract ourself: is there a protocol?
HS
February 26, 2024
6
Q.
I am interested in the Mycotoxin detection in grain extracts RFP. Can you provide a list of specific mycotoxins that would need to be measured in grain extracts?
4
A.
Thank you for the question Dr. Snow. We are looking at DON, Alfatoxin, Fumonisin, Ocratoxin and Zearalenone.
Jesse
Jesse Miller, Senior Director of Innovation, Neogen Corporation
January 8, 2024
Is this response helpful?
1
0
Q.
Is it necessary to work with internal isotop-labelled standards or is an external calibration sufficient?
HS
February 26, 2024
2
Q.
Is a validation of the method necessary (Linearity, specificity, LOD, LOQ)?
HS
February 26, 2024
2
Q.
What is your target limit of detection, test time, and repeatibiility?
1
A.
Answered in a DM, thanks John!
Jesse Miller, Senior Director of Innovation, Neogen Corporation
February 5, 2024
Is this response helpful?
0
0
Q.
Can you comment on LOD, LOQ requirements? Would you consider spectroscopic solutions?
1
A.
Private message sent Tom!
Jesse Miller, Senior Director of Innovation, Neogen Corporation
February 14, 2024
Is this response helpful?
0
0
Q.
Hello Jesse. We are an R&D innovation and consultancy company. One of our stakeholders' product may be suit your call. Is there any place where we can upload documents regarding the method performance of the product?
CS
February 14, 2024
1
A.
Hi Cenk, yes, we can have attachments on messages in the platform. Ill send you a direct message here.
Jesse
Jesse Miller, Senior Director of Innovation, Neogen Corporation
February 14, 2024
Is this response helpful?
0
0
Q.
Dear Mr. Miller, are you looking for a partner to develop an analytical method that will be transferred to your site, or do you need a partner that can analyze grain extracts and report the results to Neogen?
SN
February 20, 2024
1
A.
We are looking to do this internally and would transfer the method.
Thank you Siemon!
Jesse
Jesse Miller, Senior Director of Innovation, Neogen Corporation
February 21, 2024
Is this response helpful?
0
0
Q.
Greetings! Would Neogen be interested in a sensor system that can detect genetic biomarkers of mycotoxins? There is precedent for this approach and molecular point-of-need detection can be very sensitive. Thank you.
GH
January 10, 2024
1
A.
Sent you a DM Guillaume. Thanks!
Jesse Miller, Senior Director of Innovation, Neogen Corporation
January 10, 2024
Is this response helpful?
0
0
Q.
How high should LOD/LOQ be? What are the concentrations that should be measured?
HS
February 26, 2024
1
A.
Hi Helga. Sending you info via DM
Jesse
Jesse Miller, Senior Director of Innovation, Neogen Corporation
February 27, 2024
Is this response helpful?
0
0
Q.
Are you open to immuno-MRM approach? We have been generating immuno-MRM compatible high affinity low off rate antibodies for LC-MS detection of cancer biomarkers for NCI. Immuno-MRM allows selective concentration of the antigen (mycotoxin) and quantification.
JH
February 27, 2024
1
A.
Yes for sure. Thank you Jun!
Jesse
Jesse Miller, Senior Director of Innovation, Neogen Corporation
February 27, 2024
Is this response helpful?
0
0
Q.
Is it possible to send an attachment together with the application in relation to the validation section of the proposal?
1
Q.
I am interested in the mycotoxin detection. Could you please provide the level of detection for the desired mycotoxins? Also, are internal standards required?
1
A.
Hi Christina. Sending you a PM.
Jesse
Jesse Miller, Senior Director of Innovation, Neogen Corporation
February 21, 2024
Is this response helpful?
0
0
Q.
Is there a preferred MS method (quad, QqQ, qTOF) and a target run time (<5min, 10-15min, >20min)? And what is the expected timeline?
1
A.
Hello Carlos! We are open to all possibilities for this one, thank you!
Jesse Miller, Senior Director of Innovation, Neogen Corporation
January 22, 2024
Is this response helpful?
0
0
Q.
Please provide more details on the scope of work - e.g., desired experimental design and timeline. I can do both HPLC and LC-MS but not sure the extent of the work that I may need to include in the application/proposal.
1
A.
Hello!
What we are looking for is a potential partner to create and validate a method to detect and quantitate a diluted mycotoxin in our own proprietary mobile phase. Use of an immunoaffinity column is undesired due to the potential difference in antibody binding sites between our antibodies and the antibody on the column. We would like the process to be as simple and repeatable as possible.
Jesse Miller, Senior Director of Innovation, Neogen Corporation
January 16, 2024
Is this response helpful?
0
0
Q.
Can you please tell me the limit of detection, upper and lower limit of quantitation desired for the mycotoxins (DON, Alfatoxin, Fumonisin, Orcatoxin and Zearaleone) detection?
1
A.
Hello Shabab
I replied to your query via DM, thank you for the interest!
Jesse
Jesse Miller, Senior Director of Innovation, Neogen Corporation
January 31, 2024
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0
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