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Optimizing fermentation manufacturing processes
  • Background
  • What we're looking for
  • What we can offer you
  • Who we are
  • Q&A
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Background

Cargill operates multiple fermentation lines for products such as ethanol, lactic and citric acids, ketogluconic acid, and erythritol. Across these plants, a recurring set of performance metrics governs success: achieving high fermentation and downstream yield, reducing filter-aid and other consumables, limiting natural-gas/steam and electrical power use. 

 

Opportunities for improvement exist across several steps of the production processes. Enhancing oxygen transfer and agitation efficiency could increase volumetric productivity in aerobic systems, while advances in solids-liquid clarification could reduce product losses and lower the use of filter aids. Likewise, optimization of thermal operations used for concentration and dehydration presents additional potential to reduce natural gas and steam demand and improve overall energy efficiency.

What we're looking for

We are looking for manufacturing technologies, equipment, and process innovations that can improve the performance of fermentation-based production lines for products such as ethanol, lactic and citric acids, ketogluconic acid, and erythritol. We are open to practical, scalable innovations that enhance fermentation and downstream yield, reduce consumable usage, and/or improve energy and resource efficiency across key operations such as fermentation, clarification/filtration, and distillation/concentration.

Solutions of interest include:
  • Media preparation and nutrient packages
  • Solutions around process yield and productivity
  • Foam and contamination control systems for fermentation stability
  • Membrane or hybrid clarification that reduces diatomaceous earth consumption
  • High-efficiency aeration or agitation equipment for improved oxygen transfer
  • Power-efficient aeration and agitation systems for reduced energy demand
  • Low concentration recovery technologies for organic acid purification
  • Solid-liquid separation technologies
  • Energy-efficient distillation or evaporation systems
  • Inline sensors and digital controls for optimized fermentation performance
  • Novel liquid–liquid separation or extraction technologies
Our must-have requirements are:
  • Improves operational efficiency or sustainability by enhancing fermentation or downstream yield, reducing natural gas, steam, or power consumption, or lowering filter-aid and chemical use
  • Scalable and compatible with industrial-scale fermentation systems
  • Industrial scale deployment feasible within the next 3 to 24 months
Our nice-to-have's are:
  • Demonstrated in comparable fermentation or bioprocessing environments
  • Adaptable across different fermentation products or process configurations
What's out of scope:
  • Non-scalable lab concepts without industrial feasibility
  • Innovations focused on new product creation rather than process improvement
Acceptable technology readiness levels (TRL):
Levels 5-9
What we can offer you
Eligible partnership models:
Co-developmentLicensingSupply/purchase
Benefits:
Compensation
Budget is available to support proof-of-concept trials within pilot or commercial facilities, as well as co-development activities with R&D partners. Typical funding ranges from $50K to $300K, depending on the scope and applicability of the proposed technology. Cargill is also open to licensing agreements or direct technology adoption for in-market solutions that demonstrate clear operational benefits.
Compounds and Reagents
Samples may be shared with selected partners to support validation or testing.
Data
Selected partners may receive access to relevant process data.
Facilities and Services
Visits to pilot or production facilities may be arranged following selection.
Who we are

Our global team includes more than 1,500 research, development, applications, technical services and intellectual property specialists working in more than 200 locations. Together, they provide a spectrum of services encompassing technical service, applications, development, research, intellectual asset management, and scientific and regulatory affairs.

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Reviewers
Q&A with Cargill

The Q&A is now closed.

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Q.
Hello, we have developed machine learning models to predict various traits of cacao fruits and beans (quality, fat, moisture) using handheld NIR spectrometers. Does this fit into the scope of the call? Thank you
2
A.
Hi Jan, this challenge is not cacao specific, and more focused on general fermentation, so I would say this NIR work is probably not very well suited. Looking forward to seeing your submissions for other ideas! Best regards, Dimitris.
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Dimitris Lykomitros, Technology Scout, Cargill
November 21, 2025
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0
Q.
Are you interested in a digital solution that could help to: - ensure data is FAIR and available for statistical modeling - optimize metabolic fluxes in system - track genomic adaptations to improve strain/fermentation?
1
A.
Thank you for your question and for your interest in this challenge. At this time, we are not seeking digital solutions focused on FAIR principle data support or validation. Instead, we are looking for solutions that deliver direct optimization and cost efficiency improvements.
JR
Joseph Richards, Process & General Manufacturing Technology Lead, Cargill
November 10, 2025
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0
0
Q.
Q: Would a technique that is able to measure cell redox within the fermentor be of interest?
1
A.
Yes, this would be of interest as it can help optimize the proces.
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Dimitris Lykomitros, Technology Scout, Cargill
December 30, 2025
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0
0
Q.
Hello team, we have developed a technology based on green chemistry to remove lignin from lignocellulosic biomass (rice straw as a case study but transferable to other feedstoks), resulting in higher enzymatic hydrolysis, that it turn can improve sugar availability and remove growth inhibitors at fermentation stage. This offers potential for improved fermentation yields. Does this fit into the scope of the call? Thank you
1
A.
Hi Alfred, this would indeed be of interest.
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Dimitris Lykomitros, Technology Scout, Cargill
December 30, 2025
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